3а-хидроксистероид дехидрогеназа (А-специфична)
| 3a-hidroksisteroid dehidrogenaza (A-specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.213 | ||||||||
| CAS broj | 9028-56-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3a-hidroksisteroid dehidrogenaza (A-specifična) (EC 1.1.1.213, 3alfa-hidroksisteroid dehidrogenaza, AKR1C2, Akr1c9) je enzim sa sistematskim imenom 3alfa-hidroksisteroid:NAD(P)+ 3-oksidoreduktaza (A-specifična).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 alfa-hidroksisteroid + NAD(P)+ 3-oksosteroid + NAD(P)H + H+
Ovaj enzim deluje na više 3alfa-hidroksisteroida. Nije specifičan u pogledu NAD+ ili NADP+ (cf. EC 1.1.1.50, 3alfa-hidroksisteroid 3-dehidrogenaza, B-specifična).
Reference[уреди | уреди извор]
- ^ Björkhem, I. & Danielsson, H. (1970). „Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by Δ4-3-oxosteroid 5-β-reductase and 3-α-hydroxysteroid dehydrogenase from rat liver”. Eur. J. Biochem. 12: 80—84. PMID 4392180.
- ^ Tomkins, G.M. (1956). „A mammalian 3α-hydroxysteroid dehydrogenase”. J. Biol. Chem. 218: 437—447. PMID 13278351.
- ^ Dufort, I., Soucy, P., Labrie, F. and Luu-The, V. (1996). „Molecular cloning of human type 3 3α-hydroxysteroid dehydrogenase that differs from 20α-hydroxysteroid dehydrogenase by seven amino acids”. Biochem. Biophys. Res. Commun. 228: 474—479. PMID 8920937.
- ^ Nahoum, V., Gangloff, A., Legrand, P., Zhu, D.W., Cantin, L., Zhorov, B.S., Luu-The, V., Labrie, F., Breton, R. and Lin, S.X. (2001). „Structure of the human 3α-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-Å resolution”. J. Biol. Chem. 276: 42091—42098. PMID 11514561.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 3alpha-hydroxysteroid+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
