Абиетадиенска синтаза
| Abietadienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.18 | ||||||||
| CAS broj | 157972-08-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Abietadienska sintaza (EC 4.2.3.18, kopalil-difosfat difosfat-lijaza (ciklizacija)) je enzim sa sistematskim imenom (+)-kopalil-difosfat difosfat-lijaza (ciklizacija, formira abieta-7,13-dien).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (+)-kopalil difosfat abieta-7,13-dien + difosfat
Ovaj enzim učestvuje u biosintezi abietadiena.
Reference[уреди | уреди извор]
- ^ Peters, R.J., Flory, J.E., Jetter, R., Ravn, M.M., Lee, H.J., Coates, R.M. and Croteau, R.B. (2000). „A'bietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme”. Biochemistry. 39: 15592—15602. PMID 11112547.
- ^ Peters, R.J., Ravn, M.M., Coates, R.M. and Croteau, R.B. (2001). „Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites”. J. Am. Chem. Soc. 123: 8974—8978. PMID 11552804.
- ^ Peters, R.J. & Croteau, R.B. (2002). „Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement”. Proc. Natl. Acad. Sci. USA. 99: 580—584. PMID 11805316.
- ^ Peters, R.J. & Croteau, R.B. (2002). „Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate”. Biochemistry. 41: 1836—1842. PMID 11827528.
- ^ Ravn, M.M., Peters, R.J., Coates, R.M. and Croteau, R. (2002). „Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates”. J. Am. Chem. Soc. 124: 6998—7006. PMID 12059223.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Abieta-7,13-diene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
