Арахидонатна 12-липоксигеназа
| Arahidonatna 12-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.31 | ||||||||
| CAS broj | 82391-43-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Arahidonatna 12-lipoksigenaza (EC 1.13.11.31, Delta12-lipoksigenaza, 12-lipoksigenaza, 12Delta-lipoksigenaza, C-12 lipoksigenaza, 12S-lipoksigenaza, leukotrienska A4 sintaza, LTA4 sintaza) je enzim sa sistematskim imenom arahidonat:kiseonik 12-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- arahidonat + O2 (5Z,8Z,10E,14Z)-(12S)-12-hidroperoksiikosa-5,8,10,14-tetraenoat
Produkt se brzo redukuje do korespondirajućeg 12S-hidroksi jedinjenja.
Reference[уреди | уреди извор]
- ^ Hamberg, M. & Samuelsson, B. (1974). „Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets”. Proc. Natl. Acad. Sci. USA. 71: 3400—3404. PMID 4215079.
- ^ Nugteren, D.H. (1975). „Arachidonate lipoxygenase in blood platelets”. Biochim. Biophys. Acta. 380: 299—307. PMID 804329.
- ^ Wallach, D.P. & Brown, V.R. (1981). „A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases”. Biochim. Biophys. Acta. 663: 361—372. PMID 6783111.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Arachidonate+12-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
