Фенилаланин/тирозинска амонијак-лијаза
| Fenilalanin/tirozinska amonijak-lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.25 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fenilalanin/tirozinska amonijak-lijaza (EC 4.3.1.25, PTAL, bifunkcionalni PAL) je enzim sa sistematskim imenom L-fenilalanin(or L-tirozin):trans-cinamat(or trans-p-hidroksicinamat) amonijak-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-fenilalanin trans-cinamat + NH3;;
- (2) L-tirozin trans-p-hidroksicinamat + NH3
Ovaj enzim je član familije lijaza aromatičnih aminokiselina.
Reference[уреди | уреди извор]
- ^ Rösler, J., Krekel, F., Amrhein, N. and Schmid, J. (1997). „Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity”. Plant Physiol. 113: 175—179. PMID 9008393.
- ^ Watts, K.T., Mijts, B.N., Lee, P.C., Manning, A.J. and Schmidt-Dannert, C. (2006). „Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family”. Chem. Biol. 13: 1317—1326. PMID 17185227.
- ^ Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S. and Noel, J.P. (2006). „Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases”. Chem. Biol. 13: 1327—1338. PMID 17185228.
- ^ Schwede, T.F., Rétey, J. and Schulz, G.E. (1999). „Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile”. Biochemistry. 38: 5355—5361. PMID 10220322.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Phenylalanine/tyrosine+ammonia-lyase на US National Library of Medicine Medical Subject Headings (MeSH)
