Пикорнаин 3Ц
| Pikornain 3C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.28 | ||||||||
| CAS broj | 97162-88-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pikornain 3C (EC 3.4.22.28, pikornavirusna endopeptidaza 3C, poliovirusna proteaza 3C, rinovirusna proteaza 3C, proteaza 3C bolesti slinavka i šap, poliovirusna proteinaza 3C, rinovirusna proteinaza 3C, koksakievirusna 3C proteinaza, proteinaza 3C virusa bolesti slinavka i šap, 3C proteaza, 3C proteinaza, cisteinska proteinaza 3C, hepatitis A virusna 3C proteinaza, proteaza 3C, proteinaza 3C srodana sa nepovirusom prstenastih mrlja paradajza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje Gln-Gly veze u poliovirusnom poliproteinu. U drugim pikornavirusnim reakcijama Glu može da bude supstituisan sa Gln, i Ser ili Thr za Gly
Ovaj enzim izražavaju entero-, rino-, afto- i kardiovirusi.
Reference[уреди | уреди извор]
- ^ Ivanoff, L.A., Towatari, T., Ray, J., Korant, B.D. and Petteway, S.R. (1986). „Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli”. Proc. Natl Acad. Sci. USA. 83: 5392—5396. PMID 3016701.
- ^ Bazan, J.F. & Fletterick, R.J. (1988). „Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications”. Proc. Natl Acad. Sci. USA. 85: 7872—7876. PMID 3186696.
- ^ Kräusslich, H.-G. and Wimmer, E. (1988). „Viral proteinases”. Annu. Rev. Biochem. 57: 701—754. PMID 3052288.
- ^ Nicklin, M.J.H., Harris, K.S., Pallai, P.V. and Wimmer, E. (1988). „Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro”. J. Virol. 62: 4586—4593. PMID 2846872.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Picornain+3C на US National Library of Medicine Medical Subject Headings (MeSH)
