Želatinaza A
| Želatinaza-a | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.24 | ||||||||
| CAS broj | 146480-35-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Želatinaza-a (EC 3.4.24.24, 72-kDa želatinaza, matrična metaloproteinaza 2, tip IV kolagenaza, 3/4 kolagenaza, matrična metaloproteinaza 5, 72 kDa želatinaža tip A, kolagenaza IV, kolagenaza tip IV, MMP 2, tip IV kolagen metaloproteinaza, tip IV kolagenaza/želatinaza, matrična metaloproteinaza 2) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje želatina tipa I i kolagena tipa IV, V, VII, X. Razlaganje kolagenu sličnih sekvenci Pro-Gln-Gli-Ile-Ala-Gly-Gln
Ova endopeptidaza pripada peptidaznoj familiji M10.
Reference[uredi | uredi izvor]
- ^ Murphy, G., McAlpine, C.G., Poll, C.T. and Reynolds, J.J. (1985). „Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen”. Biochim. Biophys. Acta. 831: 49—58. PMID 2994741.
- ^ Collier, I.E., Wilhelm, S.M., Eisen, A.Z., Marmer, B.L., Grant, G.A., Seltzer, J.L., Kronberger, A., He, C., Bauer, E.A. and Goldberg, G.I. (1988). „H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen”. J. Biol. Chem. 263: 6579—6587. PMID 2834383.
- ^ Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990). „Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts-purification and activation of the precursor and enzymic properties”. Eur. J. Biochem. 194: 721—730. PMID 2269296.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- Gelatinase+A na US National Library of Medicine Medical Subject Headings (MeSH)
