4-Kidroksi-tetrahidrodipikolinatna sintaza
| 4-Kidroksi-tetrahidrodipikolinatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.3.7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-Kidroksi-tetrahidrodipikolinatna sintaza (EC 4.3.3.7, dihidropikolinatna sintetaza, dihidrodipikolinsko kiselinska sintaza, L-aspartat-4-semialdehidna hidrolijaza (dodavanja piruvata i ciklizacija), dapA (gen).) je enzim sa sistematskim imenom L-aspartat-4-semialdehid hidrolijaza (dodaje piruvat i ciklizuje, formira (4S)-4-hidroksi-2,3,4,5-tetrahidro-(2S)-dipikolinat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- piruvat + L-aspartat-4-semialdehid (2S,4S)-4-hidroksi-2,3,4,5-tetrahidrodipikolinat + H2O
Istraživanja enzima iz bakterije Escherichia coli su pokazala da se raakcija može podeliti u tri konsekutivna koraka.
Reference[uredi | uredi izvor]
- ^ Yugari, Y. & Gilvarg, C. (1965). „The condensation step in diaminopimelate synthesis”. J. Biol. Chem. 240: 4710—4716. PMID 5321309.
- ^ Blickling, S., Renner, C., Laber, B., Pohlenz, H.D., Holak, T.A. and Huber, R. (1997). „Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy”. Biochemistry. 36: 24—33. PMID 8993314.
- ^ Devenish, S.R., Blunt, J.W. and Gerrard, J.A. (2010). „NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase”. J Med Chem. 53: 4808—4812. PMID 20503968.
- ^ Soares da Costa, T.P., Muscroft-Taylor, A.C., Dobson, R.C., Devenish, S.R., Jameson, G.B. and Gerrard, J.A. (2010). „How essential is the ’essential’ active-site lysine in dihydrodipicolinate synthase”. Biochimie. 92: 837—845. PMID 20353808.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- 4-hydroxy-tetrahydrodipicolinate+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
