5-Metoksitriptamin

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5-Metoksitriptamin
IUPAC ime
2-(5-Methoxy-1H-indol-3-yl)ethanamine
Klinički podaci
Prodajno imeMexamine
Meksamin
Identifikatori
CAS broj608-07-1
PubChemCID 1833
IUPHAR/BPS107
ChemSpider1767 ДаY
KEGGC05659 ДаY
ChEMBLCHEMBL8165 ДаY
Hemijski podaci
FormulaC11H14N2O
Molarna masa190.242 g/mol
  • O(c1cc2c(cc1)ncc2CCN)C
  • InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6—9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3 ДаY
  • Key:JTEJPPKMYBDEMY-UHFFFAOYSA-N ДаY

5-Metoksitriptamin (5-MT, meksamin) je derivat triptamina. On je blisko srodan neurotransmiterima serotoninu i melatoninu. Za 5-MT je pokazano da se prirodno javlja u telu u niskim nivoima.[1] On je proizvod dekarboksilacije melatonina u epifizi.[1]

5-MT deluje kao pun agonist 5-HT1, 5-HT2, 5-HT4, 5-HT6, i 5-HT7 receptora.[2][3][4][5][6][7][8] On nema afinitet za 5-HT3 receptor. Njegov afinitet za 5-HT1E receptor je veoma slab u poređenju sa drugim 5-HT1 receptorima.[5][9]

Vidi još[uredi | uredi izvor]

Референце[uredi | uredi izvor]

  1. ^ а б Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).”. J Endocrinol. 118 (3): 389—397. PMID 2460575. doi:10.1677/joe.0.1180389. 
  2. ^ Wu PH, Gurevich N, Carlen PL (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.”. Neurosci Lett. 86 (1): 72—76. PMID 2966313. doi:10.1016/0304-3940(88)90185-1. 
  3. ^ Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.”. Eur J Pharmacol. 323 (2-3): 235—240. PMID 9128844. doi:10.1016/S0014-2999(97)00029-0. 
  4. ^ Amemiya N, Hatta S, Takemura H, Ohshika H (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.”. Eur J Pharmacol. 318 (2-3): 403—409. PMID 9016931. doi:10.1016/S0014-2999(96)00777-7. 
  5. ^ а б Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9—16. PMID 2402303. 
  6. ^ Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.”. Neuropharmacology. 36 (4-5): 713—720. PMID 9225298. doi:10.1016/S0028-3908(97)00019-1. 
  7. ^ Hemedah M, Coupar IM, Mitchelson FJ (1999). „[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.”. Br J Pharmacol. 126 (1): 179—188. PMC 1565797 Слободан приступ. PMID 10051134. doi:10.1038/sj.bjp.0702293. 
  8. ^ Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008. 
  9. ^ Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2. 

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