Atrolizin C
| Atrolizin C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.42 | ||||||||
| CAS broj | 158886-17-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Atrolizin C (EC 3.4.24.42, Crotalus atrox metaloendopeptidaza c, hemoragijsk toksin c, hemoragijski toksin d) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu i Gly23-Phe veza u B lancu insulina. Na malim molekulima postoji preferencija za hidrofobne ostatke u P2' i male ostatke poput Ala, Gly u P1
Ova hemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.
Reference[uredi | uredi izvor]
- ^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.
- ^ Fox, J.W., Campbell, R., Beggerly, L. and Bjarnason, J.B. (1986). „Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom”. Eur. J. Biochem. 156: 65—72. PMID 3514216.
- ^ Bjarnason, J.B. & Fox, J.W. (1987). „Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom”. Biochim. Biophys. Acta. 911: 356—363. PMID 3101740.
- ^ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). „Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108—121. PMID 2949699.
- ^ Shannon, J.D., Baramova, E.N., Bjarnason, J.B. and Fox, F.W. (1989). „Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin”. J. Biol. Chem. 264: 11575—11583. PMID 2745407.
- ^ Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- (1990). „2, isolated from the venom of Crotalus ruber ruber”. J. Biochem. (Tokyo). 108: 711—719. PMID 2081731.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- Atrolysin+C na US National Library of Medicine Medical Subject Headings (MeSH)
