CLIC6

Hloridni intracelularni kanal 6
Hloridni intracelularni kanal 6
Identifikatori
Simboli	CLIC6; CLIC1L
Vanjski ID	MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6 Gene
Ontologija gena
Molekularna funkcija	• aktivnost naponom kontrolisanog jonskog kanala; • aktivnost naponom kontrolisanog hloridnog kanala;
Celularna komponenta	• cytoplasm; • ćelijska membrana; • integralno sa membranom; • kompleks hloridnog kanala;
Biološki proces	• jonski transport;
Ortolozi
Vrsta	Čovek
Entrez	54102
Ensembl	ENSG00000159212
UniProt	Q96NY7
RefSeq (mRNA)	NM_053277.1
RefSeq (protein)	NP_444507.1
Lokacija (UCSC)	Chr 21:; 36.04 - 36.09 Mb
PubMed pretraga	[1]

Hloridni intracelularni kanal, protein 6 je protein koji je kod ljudi kodiran CLIC6 genom.^[1]^[2] Ovaj gen je deo velikog trostrukog regiona nađenog na hromozomima 1, 6, i 21. Alternativno splajsovane transkriptne varijante su poznate, ali njihov biološki značaj nije poznat.^[2]

Interakcije[uredi | uredi izvor]

CLIC6 formira interakcije sa dopaminskim receptorom D3.^[3]

Reference[uredi | uredi izvor]

^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). „The DNA sequence of human chromosome 21”. Nature. 405 (6784): 311—9. PMID 10830953. doi:10.1038/35012518.
^ ^а ^б „Entrez Gene: CLIC6 chloride intracellular channel 6”.
^ Griffon, Nathalie; Jeanneteau Freddy (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47—57. ISSN 0169-328X. PMID 14499480. doi:10.1016/S0169-328X(03)00283-3.

Literatura[uredi | uredi izvor]

Singh H (2010). „Two decades with dimorphic Chloride Intracellular Channels (CLICs)”. Febs letters. 584 (10): 2112—21. PMID 20226783. doi:10.1016/j.febslet.2010.03.013.
Hillier LD; Lennon G; Becker M (1997). „Generation and analysis of 280,000 human expressed sequence tags”. Genome Res. 6 (9): 807—28. PMID 8889549. doi:10.1101/gr.6.9.807.
Strippoli P; D'Addabbo P; Lenzi L (2003). „Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q”. Mamm. Genome. 13 (8): 456—62. PMID 12226712. doi:10.1007/s00335-001-2157-0.
Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scanlan MJ; Gout I; Gordon CM (2003). „Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression”. Cancer Immun. 1: 4. PMID 12747765.
Griffon N; Jeanneteau F; Prieur F (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. 117 (1): 47—57. PMID 14499480. doi:10.1016/S0169-328X(03)00283-3.
Friedli M; Guipponi M; Bertrand S (2004). „Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12”. Gene. 320: 31—40. PMID 14597386. doi:10.1016/S0378-1119(03)00830-8.
Ota T; Suzuki Y; Nishikawa T (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS; Wagner L; Feingold EA (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.

Vidi još[uredi | uredi izvor]

Hloridni kanal

Spoljašnje veze[uredi | uredi izvor]

CLIC6+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid10830953-1] Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). „The DNA sequence of human chromosome 21”. Nature. 405 (6784): 311—9. PMID 10830953. doi:10.1038/35012518.

[entrez-2] а ^б „Entrez Gene: CLIC6 chloride intracellular channel 6”.

[pmid14499480-3] Griffon, Nathalie; Jeanneteau Freddy (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47—57. ISSN 0169-328X. PMID 14499480. doi:10.1016/S0169-328X(03)00283-3.

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