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Izoleucin-tRNK ligaza (EC 6.1.1.5, izoleucil-tRNK sintetaza, izoleucil-transferna ribonukleatna sintetaza, izoleucil-transfer RNK sintetaza, izoleucin-transfer RNK ligaza, izoleucin-tRNK sintetaza, izoleucinska translaza) je enzim sa sistematskim imenom L-izoleucin:tRNKIle ligaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + L-izoleucin + tRNKIle
AMP + difosfat + L-izoleucil-tRNKIle
- ^ Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061—1067. PMID 13792726.
- ^ Berg, P., Bergmann, F.H., Ofengand, E.J. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. I. The mechanism of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid formation”. J. Biol. Chem. 236: 1726—1734.
- ^ Bergmann, F.H., Berg, P. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli”. J. Biol. Chem. 236: 1735—1740.
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| 6.1: Ugljenik-kiseonik | |
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| 6.2: Ugljenik-sumpor | |
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| 6.3: Ugljenik-azot | |
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