Karfentanil

S Vikipedije, slobodne enciklopedije
Karfentanil
Klinički podaci
Drugs.comMonografija
Identifikatori
CAS broj59708-52-0 DaY
ATC kodNone
PubChemCID 62156
DrugBankDB01535 DaY
ChemSpider55986 DaY
ChEMBLCHEMBL61084 DaY
Hemijski podaci
FormulaC24H30N2O3
Molarna masa394,507
  • CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)OC
  • InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3 DaY
  • Key:YDSDEBIZUNNPOB-UHFFFAOYSA-N ДаY

Karfentanil je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 394,507 Da.[1][2][3]

Osobine[uredi | uredi izvor]

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 0
Broj rotacionih veza 8
Particioni koeficijent[4] (ALogP) 3,6
Rastvorljivost[5] (logS, log(mol/L)) -5,0
Polarna površina[6] (PSA, Å2) 49,9

Reference[uredi | uredi izvor]

  1. ^ Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. PMID 12712038
  2. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709Slobodan pristup. PMID 21059682. doi:10.1093/nar/gkq1126. 
  3. ^ Nucleic Acids Res (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889Slobodan pristup. PMID 18048412. doi:10.1093/nar/gkm958.  |first2= zahteva |last2= u Authors list (pomoć); |first3= zahteva |last3= u Authors list (pomoć); |first4= zahteva |last4= u Authors list (pomoć); |first5= zahteva |last5= u Authors list (pomoć); |first6= zahteva |last6= u Authors list (pomoć); |first7= zahteva |last7= u Authors list (pomoć); |first8= zahteva |last8= u Authors list (pomoć)
  4. ^ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. Arhivirano iz originala 22. 07. 2014. g. Pristupljeno 13. 12. 2013. 
  5. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  6. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura[uredi | uredi izvor]

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