N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza
| N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.26 | ||||||||
| CAS broj | 57219-73-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza (EC 6.3.2.26, L-delta-(alfa-aminoadipoil)-L-cisteinil-D-valin sintetaza, ACV sintetaza, L-alfa-aminoadipil-cisteinil-valin sintetaza) je enzim sa sistematskim imenom L-2-aminoheksandioat:L-cistein:L-valin ligaza (formira AMP, invertuje valin).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 ATP + L-2-aminoheksandioat + L-cistein + L-valin + H2O 3 AMP + 3 difosfat + N-[L-5-amino-5-karboksipentanoil]-L-cisteinil-D-valin
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference[uredi | uredi izvor]
- ^ Byford, M.F., Baldwin, J.E., Shiau, C.-Y. and Schofield, C.J. (1997). „The mechanism of ACV synthetase”. Chem. Rev. 97: 2631—2649. PMID 11851475.
- ^ Theilgaard, H.B., Kristiansen, K.N., Henriksen, C.M. and Nielsen, J. (1997). „Purification and characterization of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum”. Biochem. J. 327: 185—191. PMID 9355751.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[uredi | uredi izvor]
- N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
