Somatostatinski receptor 2

Somatostatinski receptor 2
Somatostatinski receptor 2
Identifikatori
Simboli	SSTR2;
Vanjski ID	OMIM: 182452 MGI: 98328 HomoloGene: 37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost somatostatinskog receptora; • proteinsko vezivanje; • vezivanje za PDZ domen;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana; • integralno sa ćelijskom membranom;
Biološki proces	• prenos signala; • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom; • G-proteinska signalizacija, inhibicioni put adenilat ciklaze; • neuropeptidni signalni put; • interćelijska signalizacija; • respons na hranu; • varenje; • negativna regulacija ćelijske proliferacije;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6752
Ensembl	ENSG00000180616
UniProt	P30874
RefSeq (mRNA)	NM_001050
RefSeq (protein)	NP_001041
Lokacija (UCSC)	Chr 17:; 68.67 - 68.68 Mb
PubMed pretraga	[1]

Somatostatinski receptor tip 2 je protein koji je kod čoveka kodiran SSTR2 genom..^[1]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR2 u znatnoj meri izražen u velikom mozgu i bubrezima.^[2]

Interakcije[uredi | uredi izvor]

Za somatostatinski receptor 2 je pokazano interaguje sa SHANK2.^[3]

Vidi još[uredi | uredi izvor]

Somatostatinski receptor

Reference[uredi | uredi izvor]

^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics. 15 (2): 449—52. PMID 8449518. doi:10.1006/geno.1993.1088.
^ „Entrez Gene: SSTR2 somatostatin receptor 2”.
^ Zitzer, H; Hönck H H; et al. (1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. UNITED STATES. 274 (46): 32997—3001. ISSN 0021-9258. PMID 10551867. doi:10.1074/jbc.274.46.32997.

Literatura[uredi | uredi izvor]

Y, Yamada; Post SR; K, Wang; et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251—5. PMC 48214 . PMID 1346068. doi:10.1073/pnas.89.1.251.
Reubi JC, Waser B, Schaer JC, Markwalder R (1995). „Somatostatin receptors in human prostate and prostate cancer.”. J. Clin. Endocrinol. Metab. 80 (9): 2806—14. PMID 7673428. doi:10.1210/jc.80.9.2806.
S, Kagimoto; Yamada Y; A, Kubota; et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188—95. PMID 7914078. doi:10.1006/bbrc.1994.2054.
T, Fujita; Yamaji Y; M, Sato; et al. (1994). „Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.”. Life Sci. 55 (23): 1797—806. PMID 7968260. doi:10.1016/0024-3205(94)90090-6.
YC, Patel; Greenwood M; G, Kent; et al. (1993). „Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.”. Biochem. Biophys. Res. Commun. 192 (1): 288—94. PMID 8386508. doi:10.1006/bbrc.1993.1412.
S, Fukusumi; Kitada C; S, Takekawa; et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157—63. PMID 9125122. doi:10.1006/bbrc.1997.6252.
P, Jaïs; Terris B; P, Ruszniewski; et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639—44. PMID 9279525. doi:10.1046/j.1365-2362.1997.1740719.x.
F, Lopez; Estève JP; L, Buscail; et al. (1997). „The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.”. J. Biol. Chem. 272 (39): 24448—54. PMID 9305905. doi:10.1074/jbc.272.39.24448.
A, Tsutsumi; Takano H; K, Ichikawa; et al. (1997). „Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.”. Cell. Immunol. 181 (1): 44—9. PMID 9344495. doi:10.1006/cimm.1997.1193.
Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82—90. PMID 9892014. doi:10.1210/me.13.1.82.
U, Kumar; Sasi R; S, Suresh; et al. (1999). „Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.”. Diabetes. 48 (1): 77—85. PMID 9892225. doi:10.2337/diabetes.48.1.77.
Zitzer H, Richter D, Kreienkamp HJ (1999). „Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.”. J. Biol. Chem. 274 (26): 18153—6. PMID 10373412. doi:10.1074/jbc.274.26.18153.
H, Zitzer; Hönck HH; D, Bächner; et al. (2000). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.”. J. Biol. Chem. 274 (46): 32997—3001. PMID 10551867. doi:10.1074/jbc.274.46.32997.
S, Petersenn; Rasch AC; S, Presch; et al. (2000). „Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.”. Mol. Cell. Endocrinol. 157 (1-2): 75—85. PMID 10619399. doi:10.1016/S0303-7207(99)00161-6.
Kreienkamp HJ, Zitzer H, Richter D (2001). „Identification of proteins interacting with the rat somatostatin receptor subtype 2.”. J. Physiol. Paris. 94 (3-4): 193—8. PMID 11087996. doi:10.1016/S0928-4257(00)00204-7.
MK, Ho; Yung LY; JS, Chan; et al. (2001). „Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.”. Br. J. Pharmacol. 132 (7): 1431—40. PMC 1572686 . PMID 11264236. doi:10.1038/sj.bjp.0703933.
MC, Zatelli; Tagliati F; JE, Taylor; et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161—9. PMID 11344221. doi:10.1210/jc.86.5.2161.
T, Talme; Ivanoff J; M, Hägglund; et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71—9. PMC 1906108 . PMID 11472428. doi:10.1046/j.1365-2249.2001.01577.x.
DD, Klisovic; O'Dorisio MS; SE, Katz; et al. (2001). „Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.”. Invest. Ophthalmol. Vis. Sci. 42 (10): 2193—201. PMID 11527930.

Spoljašnje veze[uredi | uredi izvor]

„Somatostatin Receptors: sst₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
somatostatin+receptor+2 на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid8449518-1] Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics. 15 (2): 449—52. PMID 8449518. doi:10.1006/geno.1993.1088.

[entrez-2] „Entrez Gene: SSTR2 somatostatin receptor 2”.

[pmid10551867-3] Zitzer, H; Hönck H H; et al. (1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. UNITED STATES. 274 (46): 32997—3001. ISSN 0021-9258. PMID 10551867. doi:10.1074/jbc.274.46.32997.

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