Trimerlizin I
| Trimerlizin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.52 | ||||||||
| CAS broj | 151125-16-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trimerlizin I (EC 3.4.24.52, Trimeresurus metaloendopeptidaza I, hemoragična proteinaza HR1A, hemoragična metaloproteinaza HR1A, metaloproteinaza HR1A) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje dve veze, His10-Leu i Ala14-Leu, u lancu insulina B
Ova hemoragična endopeptidaza je prisutna u venumu zmije Trimeresurus flavoviridis.
Reference[uredi | uredi izvor]
- ^ Omori-Satoh, T. & Sadahiro, S. (1979). „Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts”. Biochim. Biophys. Acta. 580: 392—404. PMID 518906.
- ^ Yamakawa, Y. & Omori-Satoh, T. (1988). „The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)”. Toxicon. 26: 227—231. PMID 3284004.
- ^ Takeya, H., Oda, K., Miyata, T., Omori-Satoh, T. and Iwanaga, S. (1990). „The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis”. J. Biol. Chem. 265: 16068—16073. PMID 2398046.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[uredi | uredi izvor]
- Trimerelysin+I na US National Library of Medicine Medical Subject Headings (MeSH)
