Dihidrokaempferol 4-reduktaza
| Dihidrokaempferol 4-reduktaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 1.1.1.219 | ||||||||
| CAS broj | 83682-99-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dihidrokaempferol 4-reduktaza (EC 1.1.1.219, dihidroflavanol 4-reduktaza, dihidromiricetinska reduktaza, NADPH-dihidromiricetinska reduktaza, dihidrokvercetin reduktaza) je enzim sa sistematskim imenom cis-3,4-leuopelargonidin:NADP+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- cis-3,4-leukopelargonidin + NADP+ (+)-dihidrokemferol + NADPH + H+
Takođe deluje, u reverznom smeru, na (+)-dihidrokvercetin i (+)-dihidromiricetin. Svaki dihidroflavonol se redukuje do korespondirajućeg cis-flavan-3,4-diola. Može da koristi NAD[3] umesto NADP+, mada reakcija sporo teče. Dihidrokaempferolna 4-reduktaza učestvuje u biosintezi antocijanidina u biljkama.
Reference[уреди | уреди извор]
- ^ Heller, W., Forkmann, G., Britsch, L. and Grisebach, H. (1985). „Enzymatic reduction of (+)-dihydroflavonols to flavan-3,4-cis- diols with flower extracts from Matthiola incana and its role in anthocyanin biosynthesis”. Planta. 165: 284—287.
- ^ Stafford, H.A. & Lester, H.H. (1985). „Flavan-3-ol biosynthesis the conversion of (+)- dihydromyricetin to its flavan-3,4-diol (leucodelphinidin) and to (+)-gallocatechin by reductases extracted from tissue-cultures of Ginkgo biloba and Pseudotsuga-menziesii”. Plant Physiol. 78: 791—794. PMID 16664326.
- ^ +
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Dihydrokaempferol+4-reductase на US National Library of Medicine Medical Subject Headings (MeSH)
