Farmakogenetika

Farmakogenetika se bavi genetičkim razlikama u metaboličkim putevima koji utiču na individualne response na lekove, u pogledu terapeutskog dejstva i nuspojava.

U onkologiji se farmakogenetika tradicionalno odnosi na gonocitne mutacije (e.g., jednonukleotidne polimorfizame gena koji kodiraju enzime jetre odgovorne za uklanjanje lekova i farmakokinetiku), dok se farmakogenomika odnosi na somatske mutacije u tumorskoj DNK koji uzrokuju promene u responsu na lek (e.g., KRAS mutacije kod pacijenata tretiranih sa anti-Her1 biološkim agensima).

Literatura

• Abbott A (2003). „With your genes? Take one of these, three times a day”. Nature. 425 (6960): 760—2. PMID 14574377. doi:10.1038/425760a. 
• Evans WE, McLeod HL (2003). „Pharmacogenomics – drug disposition, drug targets, and side effects”. N. Engl. J. Med. 348 (6): 538—49. PMID 12571262. doi:10.1056/NEJMra020526. 
• Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (2001). „Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review”. JAMA. 286 (18): 2270—9. PMID 11710893. doi:10.1001/jama.286.18.2270. 
• Weinshilboum R; Collins, Francis S.; Weinshilboum, Richard (2003). „Inheritance and drug response”. N. Engl. J. Med. 348 (6): 529—37. PMID 12571261. doi:10.1056/NEJMra020021. 

Vidi još

• Farmakogenomika
• Hemogenomika
• Strukturna genomika

Spoljašnje veze

• Pharmacogenomics: Medicine and the new genetics from the Human Genome Project
• Pharmacogenomics in Drug Discovery and Development, a book on pharmacogenomics, diseases, personalized medicine, and therapeutics
• The Pharmacogenomics Journal
• PharmGKB The Pharmacogenetics and Pharmacogenomics Knowledge Base, a free online tool for Pharmacogenetics research