Glikolipid 6-a-manoziltransferaza
| Glikolipid 6-a-manoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.232 | ||||||||
| CAS broj | 346003-17-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glikolipid 6-a-manoziltransferaza (EC 2.4.1.232, alfa-1,6-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza, GDP-manoza:glikolipid 1,6-alfa-D-manoziltransferaza, glikolipid 6-alfa-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza) je enzim sa sistematskim imenom GDP-manoza:oligosaharid 6-alfa-D-manoziltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Prenosi alfa-D-manozilni ostatak sa GDP-manoze na oligosaharid vezan za lipid, formira alfa-(1->6)-D-manozil-D-manoznu vezu
Za dejstvo ovog enzima je neophodan Mn2+. Kod Saccharomyces cerevisiae ovaj enzim katalizuje esencijalni korak elongacije spoljašnjeg lanca N-vezanih oligosaharida. Man8GlcNAc i Man9GlcNAc su jednako dobri supstrati.
Reference[уреди | уреди извор]
- ^ Romero, P.A. & Herscovics, A. (1989). „Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of α-1,6-mannosyltransferase which initiates outer chain formation”. J. Biol. Chem. 264: 1946—1950. PMID 2644248.
- ^ Reason, A.J., Dell, A., Romero, P.A. and Herscovics, A. (1991). „Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae”. Glycobiology. 1: 387—391. PMID 1820199.
- ^ Nakanishi-Shindo, Y., Nakayama, K., Tanaka, A., Toda, Y. and Jigami, Y. (1993). „Structure of the N-linked oligosaccharides that show the complete loss of α-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae”. J. Biol. Chem. 268: 26338—26345. PMID 8253757.
- ^ Yamamoto, K., Okamoto, M., Yoko-o, T. and Jigami, Y. (2003). „Salt stress induces the expression of the Schizosaccharomyces pombe och1+, which encodes an initiation-specific α-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins”. Biosci. Biotechnol. Biochem. 67: 927—929. PMID 12784644.
- ^ Cui, Z., Horecka, J. and Jigami, Y. (2002). „Cdc4 is involved in the transcriptional control of OCH1, a gene encoding α-1,6-mannosyltransferase in Saccharomyces cerevisiae”. Yeast. 19: 69—77. PMID 11754484.
- ^ Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y. (2001). „Schizosaccharomyces pombe och1+ gene encoding α-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation”. Jpn. Kokai Tokkyo Koho. Koho: 11—11.
- ^ Nakayama, K., Nakanishi-Shindo, Y., Tanaka, A., Haga-Toda, Y. and Jigami, Y. (1997). „Substrate specificity of α-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae”. FEBS Lett. 412: 547—550. PMID 9276464.
- ^ Suzuki, A., Shibata, N., Suzuki, M., Saitoh, F., Takata, Y., Oshie, A., Oyamada, H., Kobayashi, H., Suzuki, S. and Okawa, Y. (1996). „Characterization of α-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan”. Eur. J. Biochem. 240: 37—44. PMID 8797833.
- ^ Yip, C.L., Welch, S.K., Klebl, F., Gilbert, T., Seidel, P., Grant, F., O'Hara, P.J. and MacKay, V.L. (1994). „Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins”. Proc. Natl. Acad. Sci. USA. 91: 2723—2727. PMID 8146181.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Initiation-specific+alpha-1,6-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
