Lipoat—protein ligaza
| Lipoat—protein ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.63 | ||||||||
| CAS broj | 144114-18-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lipoat—protein ligaza (EC 2.7.7.63, LplA, lipoat proteinska ligaza, lipoat-proteinska ligaza A, LPL, LPL-B) je enzim sa sistematskim imenom ATP:lipoat adenililtransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za rad ovog enzima je neophodan jon Mg2+.
Reference[уреди | уреди извор]
- ^ Morris, T.W., Reed, K.E. and Cronan, J.E., Jr. (1994). „Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product”. J. Biol. Chem. 269: 16091—16100. PMID 8206909.
- ^ Green, D.E., Morris, T.W., Green, J., Cronan, J.E., Jr. and Guest, J.R. (1995). „Purification and properties of the lipoate protein ligase of Escherichia coli”. Biochem. J. 309: 853—862. PMID 7639702.
- ^ Zhao, X., Miller, J.R., Jiang, Y., Marletta, M.A. and Cronan, J.E. (2003). „Assembly of the covalent linkage between lipoic acid and its cognate enzymes”. Chem. Biol. 10: 1293—1302. PMID 14700636.
- ^ Kim do, J., Kim, K.H., Lee, H.H., Lee, S.J., Ha, J.Y., Yoon, H.J. and Suh, S.W. (2005). „Crystal structure of lipoate-protein ligase A bound with the activated intermediate: insights into interaction with lipoyl domains”. J. Biol. Chem. 280: 38081—38089. PMID 16141198.
- ^ Fujiwara, K., Toma, S., Okamura-Ikeda, K., Motokawa, Y., Nakagawa, A. and Taniguchi, H. (2005). „Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site”. J. Biol. Chem. 280: 33645—33651. PMID 16043486.
- ^ Jordan, S.W. & Cronan, J.E., Jr. (1997). „A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli and mitochondria”. J. Biol. Chem. 272: 17903—17906. PMID 9218413.
- ^ Perham, R.N. (2000). „Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions”. Annu. Rev. Biochem. 69: 961—1004. PMID 10966480.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Lipoate---protein+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
