Mikrobna kolagenaza
| Mikrobna kolagenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.3 | ||||||||
| CAS broj | 2593923 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mikrobna kolagenaza (EC 3.4.24.3, Clostridium histolyticum kolagenaza, klostridiopeptidaza A, kolagenaza A, kolagenaza I, Achromobacter iophagus kolagenaza, kolagenaza, aspergilopeptidaza C, nukleolizin, azokolaza, metalokolagenaza, soikolagestin, Clostridium histolyticum proteinaza A, klostridiopeptidaza II, MMP-8, klostridiopeptidaza I, kolagenska peptidaza, kolagenska proteaza, kolagenaza MMP-1, metaloproteinaza-1, kolaza, matriks metaloproteinaza-1, MMP-1, matriks metaloproteinaza-8, matriks metaloproteinaza-18) je enzim.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Varenje prirodnog kolagena u regionu trostrukog heliksa na -Gly vezama. Na sintetičkim peptidima preferentno deluje na Gly u P3 i P1', Pro i Ala u P2 i P2', i hidroksiprolin, Ala ili Arg u P3'
Ovaj enzim je jedan od šest metaloendopeptidaza koji deluju na prirodni kolagen i koji su prisutni u medijumu bakterije Clostridium histolyticum.
Reference[уреди | уреди извор]
- ^ Hanada, K., Mizutani, T., Yamagishi, M., Tsuji, H., Misaki, T. Sawada, J. (1973). „The isolation of collagenase and its enzymological and physico-chemical properties”. Agric. Biol. Chem. 37: 1771—1781.
- ^ Merkel, J.R. & Dreisbach, J.H. (1978). „Purification and characterization of a marine bacterial collagenase”. Biochemistry. 17: 2857—2863. PMID 210785.
- ^ Heindl, M.-C., Fermandjian, S. and Keil, B. (1980). „Circular dichroism comparative studies of two bacterial collagenases and thermolysin”. Biochim. Biophys. Acta. 624: 51—59. PMID 6250633.
- ^ Labadie, J. & Montel, M..-C. (1982). „Purification et étude de quelques propriétés d’une collagénase produite par Empedobacter collagenolyticum”. Biochimie. 64: 49—54. PMID 6530724.
- ^ Bond, M.D & Van Wart, H.D. (1984). „Characterization of the individual collagenases from Clostridium histolyticum”. Biochemistry. 23: 3085—3091. PMID 6087888.
- ^ Bond, M.D. & Van Wart, H.D. (1984). „Relationship between the individual collagenases of Clostridium histolyticum: evidience for evolution by gene duplication”. Biochemistry. 23: 3092—3099. PMID 6087889.
- ^ Van Wart, H.D. & Steinbrink, D.R. (1985). „Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum”. Biochemistry. 24: 6520—6526. PMID 3002445.
- ^ Tong, N.T., Tsugita, A. and Keil-Dlouha, V. (1986). „Purification and characterization of two high-molecular-mass forms of Achromobacter collagenase”. Biochim. Biophys. Acta. 874: 296—304.
- ^ Endo, A., Murakawa, S., Shimizu, H. and Shiraishi, Y. (1987). „Purification and properties of collagenase from a Streptomyces species”. J. Biochem. (Tokyo). 102: 163—170. PMID 2822678.
- ^ Makinen, K.K. & Makinen, P.-L. (1987). „Purification and properties of an extracellular collagenolytic protease produced by the human oral bacterium Bacillus cereus (strain Soc 67)”. J. Biol. Chem. 262: 12488—12495. PMID 3040751.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Microbial+collagenase на US National Library of Medicine Medical Subject Headings (MeSH)
