Protopin
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| Nazivi | |
|---|---|
| IUPAC naziv
7-Metil-6,8,9,16-tetrahidrobis[1,3]benzodioksolo[4,5-c:5',6'-g]azecin-15(7H)-on
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| Identifikacija | |
3D model (Jmol)
|
|
| ECHA InfoCard | 100.004.546 |
| |
| Svojstva | |
| C20H19NO5 | |
| Molarna masa | 353,369 g/mol |
| Agregatno stanje | beli kristali |
| Gustina | 1,399 g/cm3 |
| Tačka topljenja | 208°C |
| nerastvoran je | |
| Rastvorljivost u hloroform | 1:15 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Protopin je benzilizohinolinski alkaloid koji se javlja u maku[4], Corydalis krtolama[5] i drugim biljkama iz familije (lat. papaveraceae), kao i dimnjača (lat. Fumaria officinalis).[6] Utvrđeno je da inhibira histaminske H1 receptore i zgrušavanje krvi, i da deluje kao analgetik.[7]
Reference[уреди | уреди извор]
- ^ The Merck Index (9 изд.). New Jersey: Merck & Co. 1976. стр. 1023.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ The Free Dictionary: Protopine
- ^ Jiang, B; Cao, K; Wang, R (2004). „Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.”. European Journal of Pharmacology. 506 (2): 93—100. PMID 15588728. doi:10.1016/j.ejphar.2004.11.004.
- ^ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). „Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR”. Toxicology Letters. 203 (2): 135—141. PMID 21419197. doi:10.1016/j.toxlet.2011.03.015.
- ^ Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). „Anti-thrombotic and anti-inflammatory activities of protopine.”. Pharmacological research : the official journal of the Italian Pharmacological Society. 36 (1): 1—7. PMID 9368908. doi:10.1006/phrs.1997.0195.
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Literatura[уреди | уреди извор]
- The Merck Index (9 изд.). New Jersey: Merck & Co. 1976. стр. 1023.
