Tetrahidrokanabinolinska kiselina sintaza
| Tetrahidrokanabinolinska kiselina sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.3.7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tetrahidrokanabinolinska kiselina sintaza (EC 1.21.3.7, THCA sintaza, Delta1-tetrahidrokanabinolna kiselina sintaza) je enzim sa sistematskim imenom kanabigerolat:kiseonik oksidoreduktaza (ciklizacija, formira Delta9-tetrahidrokanabinolat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- kanabigerolat + O2 Delta9-tetrahidrokanabinolat + H2O2
Ovaj enzim je flavoprotein (FAD). Kofaktor je kovalentno vezan.
Reference[уреди | уреди извор]
- ^ Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. (1995). „First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis”. J. Am. Chem. Soc. 117: 9766—9767.
- ^ Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. (2004). „The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ1-tetrahydrocannabinolic acid synthase from Cannabis sativa L”. J. Biol. Chem. 279: 39767—39774. PMID 15190053.
- ^ Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. (2005). „Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 799—801. PMID 16511162.
- ^ Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. (2012). „Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa”. J. Mol. Biol.: —. PMID 22766313.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Tetrahydrocannabinolic+acid+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
