WAY-213,613

С Википедије, слободне енциклопедије
WAY-213,613
IUPAC ime
(2S)-2-amino-4-[4-(2-bromo-4,5-difluorofenoksi)anilino]-4-oksobutanoinska kiselina
Identifikatori
CAS broj868359-05-1 ДаY
ATC kodnone
PubChemCID 11531745
Hemijski podaci
FormulaC16H13BrF2N2O4
Molarna masa415,186 g/mol
  • C1=CC(=CC=C1NC(=O)C[C@@H](C(=O)O)N)OC2=CC(=C(C=C2Br)F)F

WAY-213,613 je lek koji deluje kao inhibitor preuzimanja za podtip glutamatnog transportera EAAT2. On je selektivan u odnosu na druge podtipove glutamatnih transportera, i visoko je selektivan u odnosu na metabotropne i jonotropne glutamatne receptore.[1] It is used in scientific research into the function of the glutamate transporters.[2]

Reference[уреди | уреди извор]

  1. ^ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A; et al. (2005). „Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2”. Molecular Pharmacology. 68 (4): 974—82. PMID 16014807. doi:10.1124/mol.105.012005. 
  2. ^ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). „Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells”. Neuroscience. 161 (3): 794—805. PMID 19364521. doi:10.1016/j.neuroscience.2009.04.017. 

Spoljašnje veze[уреди | уреди извор]

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