Алфред Г. Гилман

Из Википедије, слободне енциклопедије
Алфред Г. Гилман

енгл. Alfred Goodman Gilman
енгл. Alfred Goodman Gilman

Општи подаци
Датум рођења 1. јул 1941.
Место рођења Њу Хејвен (САД)
Поље Фармакологија
Институција Case Western Reserve University
Познат по Г-протеин
Награде Nobel prize medal.svg Нобелова награда за физиологију или медицину (1994.)

Алфред Гудман Гилман (енгл. Alfred Goodman Gilman; Њу Хејвен, 1. јул 1941) је амерички биохемичар и фармаколог, који се прославио открићем Г-протеина и улогом протеина у преносу сигнала у ћелијама. За ово откриће додељена му је Нобелова награда за физиологију или медицину, заједно са Мартином Родбелом 1994.



  • Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures. Science. 1971 Oct 15;174(6):292. PMID 4330303.
  • Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells. Nature. 1971 Dec 10;234(5328):356-8. PMID 4332686.
  • Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems. Science. 1972 Jul 21;177(45):279-80. PMID 4339302.
  • The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem. 1981 Nov 25;256(22):11517-26. PMID 6271754.
  • The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein. J Biol Chem. 1981 Dec 25;256(24):12911-9. PMID 6273414.
  • Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase. J Biol Chem. 1982 Jan 10;257(1):20-3. PMID 6273425.
  • The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem. 1982 Oct 10;257(19):11416-23. PMID 6288684.
  • The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem. 1983 Jun 10;258(11):7059-63. PMID 6304074.
  • The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem. 1983 Sep 25;258(18):11361-8. PMID 6309843.
  • The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem. 1983 Sep 25;258(18):11369-76. PMID 6309844.
  • Homologies between signal transducing G proteins and ras gene products. Science. 1984 Nov 16;226(4676):860-2. PMID 6436980.
  • G proteins and dual control of adenylate cyclase. Cell. 1984 Mar;36(3):577-9. PMID 6321035.
  • Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell. 1984 Dec;39(2 Pt 1):301-8. PMID 6094010.
  • Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science. 1985 Sep 20;229(4719):1274-7. PMID 3839937.
  • Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science. 1989 Feb 10;243(4892):804-7. PMID 2536957.
  • Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science. 1989 Jun 30;244(4912):1558-64. PMID 2472670.
  • Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science. 1991 Dec 6;254(5037):1500-3. PMID 1962211.
  • Inhibition of adenylyl cyclase by Gi alpha. Science. 1993 Jul 9;261(5118):218-21. PMID 8327893.
  • Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 1994 Mar 17;368(6468):255-7. PMID 8145826.
  • Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science. 1994 Sep 2;265(5177):1405-12. DOI|10.1126/science.8073283 PMID 8073283.
  • Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science. 1995 Jun 23;268(5218):1769-72. PMID 7792604.
  • Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science. 1995 Nov 10;270(5238):954-60. PMID 7481799.
  • The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 1995 Dec 15;83(6):1047-58. PMID 8521505.
  • GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell. 1996 Aug 9;86(3):445-52. DOI|10.1016/S0092-8674(00)80117-8 PMID 8756726.
  • Crystal structure of the adenylyl cyclase activator Gsalpha. Science. 1997 Dec 12;278(5345):1943-7. PMID 9395396.
  • Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997 Dec 12;278(5345):1907-16. PMID 9417641.


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