11-Dehidrotromboksan B2

11-Dehidrotromboksan B2
Nazivi
	IUPAC naziv (Z)-7-[(2R,3S,4S)-4-hidroksi-2-[(E,3S)-3-hidroksiokt-1-enil]-6-okso-tetrahidropiran-3-il]hept-5-enoinska kiselina
	Drugi nazivi 11-Dehidro-tromboksan B2
Identifikacija
CAS broj	67910-12-7;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:28667;
ChemSpider	4444414 ;
KEGG	C05964;
PubChem C ID	5280891;
	SMILES O=C1O[C@H](/C=C/[C@@H](O)CCCCC)[C@H]([C@@H](O)C1)C\C=C/CCCC(=O)O; ; ; ; ; ;
Svojstva
Hemijska formula	C20H32O6
Molarna masa	368,46
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

11-dehidrotromboksan B2 (11-dehidro-TXB2) se formira razlaganjem tromboksana A2. Njega otpušataju aktivirani trombociti. Urinski nivoi 11-dehidro-TXB2 se mogu koristiti za praćenje responsa na terapiju aspirinom, kad se koristi za sprečavanje srčane bolesti,^[4] kao i bolesti kod kojih je prominentna aktivacija trombocita.^[5]

Reference[уреди | уреди извор]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). „A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease”. Eur Heart J. 28 (14): 1702—1708. PMID 17569678. doi:10.1093/eurheartj/ehm226.
^ Catella F, Healy D, Lawson JA, FitzGerald GA (1986). „11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation”. PNAS. 83 (16): 5861—5865. PMC 386396 . PMID 3461463. doi:10.1073/pnas.83.16.5861. Архивирано из оригинала 23. 10. 2015. г. Приступљено 27. 10. 2012.

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). „A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease”. Eur Heart J. 28 (14): 1702—1708. PMID 17569678. doi:10.1093/eurheartj/ehm226.

[5] Catella F, Healy D, Lawson JA, FitzGerald GA (1986). „11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation”. PNAS. 83 (16): 5861—5865. PMC 386396 . PMID 3461463. doi:10.1073/pnas.83.16.5861. Архивирано из оригинала 23. 10. 2015. г. Приступљено 27. 10. 2012.

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