2'-Hidroksikokain

2'-Hidroksikokain
IUPAC ime
	metil (1R,2R,3S,5S)-3-(2-hidroksibenzoiloksi)-8-metil-8-azabiciklo[3.2.1] oktane-2-karboksilat
Identifikatori
ATC kod	none
PubChem	CID 10519659
Hemijski podaci
Formula	C17H21NO5
Molarna masa	319,351
	SMILES CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3O)C(=O)OC; ;

2'-Hidroksikokain (Salicilmetilekgonin) je tropanski derivat koji je sintetički analog i mogući aktivni metabolit kokaina.^[1] Njegova potentnost in vitro je oko deset puta veća od kokaina,^[2] mada je samo tri puta potentniji od kokaina kad se ispituje na miševima.^[3]

Vidi još[уреди | уреди извор]

Reference[уреди | уреди извор]

^ Singh S, Basmadjian GP, Avor K, Pouw B, Seale TW. A convenient synthesis of 2'- or 4'-hydroxycocaine. Synthetic Communications. 1997;27(22):4003-4012.
^ el-Moselhy TF, Avor KS, Basmadjian GP. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie (Weinheim). 2001 Sep;334(8-9):275-8. PMID 11688137
^ Seale TW, Avor K, Singh S, Hall N, Chan HM, Basmadjian GP. 2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding. Neuroreport. 10 November 1997;8(16):3571-5. PMID 9427328

[1] Singh S, Basmadjian GP, Avor K, Pouw B, Seale TW. A convenient synthesis of 2'- or 4'-hydroxycocaine. Synthetic Communications. 1997;27(22):4003-4012.

[2] -Moselhy TF, Avor KS, Basmadjian GP. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie (Weinheim). 2001 Sep;334(8-9):275-8. PMID 11688137

[3] Seale TW, Avor K, Singh S, Hall N, Chan HM, Basmadjian GP. 2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding. Neuroreport. 10 November 1997;8(16):3571-5. PMID 9427328

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