2-Iminoacetatna sintaza
(преусмерено са 2-iminoacetatna sintaza)
| 2-Iminoacetatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.19 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Iminoacetatna sintaza (EC 4.1.99.19, thiH (gen)) je enzim sa sistematskim imenom L-tirozin 4-metilfenol-lijaza (formira 2-iminoacetat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-tirozin + S-adenozil-L-metionin + redukovani akceptor 2-iminoacetat + 4-metilfenol + 5'-dezoksiadenozin + L-metionin + akceptor + 2 H+
Ovaj enzim sadrži 4Fe-4S kluster.
Reference[уреди | уреди извор]
- ^ Leonardi, R., Fairhurst, S.A., Kriek, M., Lowe, D.J. and Roach, P.L. (2003). „Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex”. FEBS Lett. 539: 95—99. PMID 12650933.
- ^ Kriek, M., Martins, F., Challand, M.R., Croft, A. and Roach, P.L. (2007). „Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine”. Angew. Chem. Int. Ed. Engl. 46: 9223—9226. PMID 17969213.
- ^ Kriek, M., Martins, F., Leonardi, R., Fairhurst, S.A., Lowe, D.J. and Roach, P.L. (2007). „Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro”. J. Biol. Chem. 282: 17413—17423. PMID 17403671.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 2-iminoacetate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)