24,25-Dihidroksiholekalciferol

Из Википедије, слободне енциклопедије
24,25-Dihidroksiholekalciferol
IUPAC ime
Drugi nazivi 24,25-dihidroksivitamin D3
(24R)-hidroksikalcifediol
(24R)-hidroksikalcidiol
Identifikacija
CAS registarski broj 40013-87-4 YesY
PubChem[1][2] 6434253
ChemSpider[3] 4939193 YesY
ChEMBL[4] CHEMBL47183 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C27H44O3
Molarna masa 416,63 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

24,25-Dihidroksiholekalciferol (24,25-dihidroksivitamin D3, (24R)-hidroksikalcidiol, 24(R),25-(OH)2D3)[5] je jedinjenje koje je blisko srodno sa 1,25-dihidroksivitamin D3, aktivnom formom vitamina D3, ali je poput samog vitamina D3 i 25-hidroksivitamina D3 neaktivan kao hormon in vitro[6] i in vivo.[7][8]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ^ "Nomenclature of Vitamin D. Recommendations 1981. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN)" reproduced at the Queen Mary, University of London website. Retrieved 21 March 2010.
  6. ^ Sørnes, S.; Bjøro, T.; Berg, J. P.; Torjesen, P. A.; Haug, E. (1994). „Calcitriol attenuates the basal and vasoactive intestinal peptide-stimulated cAMP production in prolactin-secreting rat pituitary (GH4C1) cells“. Molecular and cellular endocrinology 101 (1–2): 183–188. PMID 9397951. 
  7. ^ Mortensen, B. M.; Gautvik, K. M.; Gordeladze, J. O. (1993). „Bone turnover in rats treated with 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3 or 24,25-dihydroxyvitamin D3“. Bioscience reports 13 (1): 27–39. PMID 8392394. 
  8. ^ Holick, MF; Schnoes, HK; Deluca, HF; Gray, RW; Boyle, IT; Suda, T (1972). „Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney“. Biochemistry 11 (23): 4251–5. DOI:10.1021/bi00773a009. PMID 4342902. 

Literatura[уреди]

  • Mata-Granados, J. M.; Luque De Castro, M. D.; Quesada Gomez, J. M. (2008). „Inappropriate serum levels of retinol, α-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: Simultaneous assessment by HPLC“. Clinical Biochemistry 41: 676–680. DOI:10.1016/j.clinbiochem.2008.02.003. PMID 18313404.. 

Spoljašnje veze[уреди]