3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza

Из Википедије, слободне енциклопедије
3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza
Identifikatori
EC broj 4.2.1.107
CAS broj 152787-68-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza (EC 4.2.1.107, 46 kDa hidrataza 2, (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza) je enzim sa sistematskim imenom (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza (formira (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA \rightleftharpoons (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA + H2O

Ovaj enzim je deo peroksizomalnog multifunktionalnog enzim perMFE-2 kod pacova.

Reference[уреди]

  1. ^ Qin, Y.M., Haapalainen, A.M., Conry, D., Cuebas, D.A., Hiltunen, J.K. and Novikov, D.K. (1997). „Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis“. Biochem. J. 328: 377-382. PMID 9371691. 
  2. ^ Xu, R. and Cuebas, D.A. (1996). „The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids“. Biochem. Biophys. Res. Commun. 221: 271-278. PMID 8619845. 
  3. ^ Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M. (1988). „Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid“. Chem. Pharm. Bull. 36: 134-141. 
  4. ^ Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M. (1988). „Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid“. Chem. Pharm. Bull. 36: 142-145. 
  5. ^ Kurosawa, T., Sato, M., Nakano, H., Fujiwara, M., Murai, T., Yoshimura, T. and Hashimoto, T. (2001). „Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis“. Steroids 66: 107-114. PMID 11146090. 
  6. ^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis“. Annu. Rev. Biochem. 72: 137-174. PMID 12543708. 

Literatura[уреди]

Spoljašnje vezе[уреди]