5-(Karboksiamino)imidazolna ribonukleotid mutaza
| 5-(Karboksiamino)imidazolna ribonukleotid mutaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 5.4.99.18 | ||||||||
| CAS broj | 255379-40-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5-(Karboksiamino)imidazolna ribonukleotid mutaza (EC 5.4.99.18, N5-CAIR mutaza, PurE, N5-karboksiaminoimidazol ribonukleotidna mutaza, klasa I PurE) je enzim sa sistematskim imenom 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol karboksimutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat
Kod eubakterija, gljiva i biljiki, ovaj enzim, zajedno sa EC 6.3.4.18, 5-(karboksiamino)imidazol ribonukleotidnom sintazom, je nephodan za izvođenje reakcije koju katalizuje enzim EC 4.1.1.21, fosforibozilaminoimidazolna karboksilaza, kod kičmenjaka.
Reference[уреди | уреди извор]
- ^ Meyer, E., Leonard, N.J., Bhat, B., Stubbe, J. and Smith, J.M. (1992). „Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry. 31: 5022—5032. PMID 1534690.
- ^ Mueller, E.J., Meyer, E., Rudolph, J., Davisson, V.J. and Stubbe, J. (1994). „N5-Carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry. 33: 2269—2278. PMID 8117684.
- ^ Meyer, E., Kappock, T.J., Osuji, C. and Stubbe, J. (1999). „Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase”. Biochemistry. 38: 3012—3018. PMID 10074353.
- ^ Mathews, I.I., Kappock, T.J., Stubbe, J. and Ealick, S.E. (1999). „Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway”. Structure. 7: 1395—1406. PMID 10574791.
- ^ Firestine, S.M., Poon, S.W., Mueller, E.J., Stubbe, J. and Davisson, V.J. (1994). „Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms”. Biochemistry. 33: 11927—11934. PMID 7918411.
- ^ Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R. and Davisson, V.J. (1998). „Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis”. Arch. Biochem. Biophys. 351: 123—134. PMID 9500840.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 5-(carboxyamino)imidazole+ribonucleotide+mutase на US National Library of Medicine Medical Subject Headings (MeSH)
