6-Oksokamforna hidrolaza
| 6-Oksokamforna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.7.1.18 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
6-Oksokamforna hidrolaza (EC 3.7.1.18, OCH, camK (gen)) je enzim sa sistematskim imenom bornan-2,6-dion hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- bornan-2,6-dion + H2O [(1S)-4-hidroksi-2,2,3-trimetilciklopent-3-enil]acetat
Ovaj enzim je izolovan iz Rhodococcus sp.
Reference[уреди | уреди извор]
- ^ Grogan, G., Roberts, G.A., Bougioukou, D., Turner, N.J. and Flitsch, S.L. (2001). „The desymmetrization of bicyclic β-diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily”. J. Biol. Chem. 276: 12565—12572. PMID 11278926.
- ^ Whittingham, J.L., Turkenburg, J.P., Verma, C.S., Walsh, M.A. and Grogan, G. (2003). „The 2-Å crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamily”. J. Biol. Chem. 278: 1744—1750. PMID 12421807.
- ^ Leonard, P.M. & Grogan, G. (2004). „Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-α-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog”. J. Biol. Chem. 279: 31312—31317. PMID 15138275.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 6-oxocamphor+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
