B-adrenergički-receptor kinaza
(преусмерено са ADRBK1)
| B-adrenergički-receptor kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.15 | ||||||||
| CAS broj | 102925-39-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
B-adrenergički-receptor kinaza (EC 2.7.11.15, ATP:beta-adrenergički-receptor fosfotransferaza, beta-adrenergički receptor-specifična kinaza, beta-AR kinaza, beta-ARK, beta-ARK 1, beta-ARK 2, beta-receptor kinaza, GRK2, GRK3, beta-adrenergički-receptor kinaza (fosforilacija), beta2ARK, betaARK1, beta-adrenoceptor kinaza, beta-adrenoceptor kinaza 1, beta-adrenoceptor kinaza 2, ADRBK1, BARK1, adrenergički receptor kinaza, STK15) je enzim sa sistematskim imenom ATP:(beta-adrenergic receptor) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).
Reference[уреди | уреди извор]
- ^ Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G. (1987). „Purification and characterization of the β-adrenergic receptor kinase”. J. Biol. Chem. 262: 9026—9032. PMID 3036840.
- ^ Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L. (1993). „Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system”. Receptor. 3: 39—55. PMID 8394172.
- ^ Laugwitz, K.L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schomig, A. and Ungerer, M. (1997). „Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes”. Cardiovasc Res. 35: 324—333. PMID 9349395.
- ^ Ferguson, S.S., Menard, L., Barak, L.S., Koch, W.J., Colapietro, A.M. and Caron, M.G. (1995). „Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by betaARK1”. J. Biol. Chem. 270: 24782—24789. PMID 7559596.
- ^ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626—633. PMID 14654303.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Beta-adrenergic-receptor+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
