Aldehid dehidrogenaza (FAD-nezavisna)
| Aldehid dehidrogenaza (FAD-nezavisna) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.99.7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aldehid dehidrogenaza (FAD-nezavisna) (EC 1.2.99.7, aldehidna oksidaza, aldehidna oksidoreduktaza, Mop, AORDd) je enzim sa sistematskim imenom aldehid:akceptor oksidoreduktaza (FAD-nezavisna).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- aldehid +H2O + akceptor karboksilat + redukovani akceptor
Ovaj enzim pripada familiji ksantinskih oksidaza. Enzim iz Desulfovibrio sp. sadrži molibden-molibdopterin-citozin dinukleotidni (MCD) kompleks i dva tipa [2Fe-2S] klaster po monomeru. On ne sadrži FAD.
Reference[уреди | уреди извор]
- ^ Uchida, H., Kondo, D., Yamashita, A., Nagaosa, Y., Sakurai, T., Fujii, Y., Fujishiro, K., Aisaka, K. and Uwajima, T. (2003). „Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690”. FEMS Microbiol. Lett. 229: 31—36. PMID 14659539.
- ^ Duarte, R.O., Archer, M., Dias, J.M., Bursakov, S., Huber, R., Moura, I., Romao, M.J. and Moura, J.J. (2000). „Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774”. Biochem. Biophys. Res. Commun. 268: 745—749. PMID 10679276.
- ^ Andrade, S.L., Brondino, C.D., Feio, M.J., Moura, I. and Moura, J.J. (2000). „Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491. EPR assignment of the proximal [2Fe-2S] cluster to the Mo site”. Eur. J. Biochem. 267: 2054—2061. PMID 10727945.
- ^ Romao, M.J., Archer, M., Moura, I., Moura, J.J., LeGall, J., Engh, R., Schneider, M., Hof, P. and Huber, R. (1995). „Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas”. Science. 270: 1170—1176. PMID 7502041.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Aldehyde+dehydrogenase+(FAD-independent) на US National Library of Medicine Medical Subject Headings (MeSH)
