Aminobutiraldehid dehidrogenaza
| Aminobutiraldehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.19 | ||||||||
| CAS broj | 9028-98-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aminobutiraldehid dehidrogenaza (EC 1.2.1.19, gama-guanidinobutiraldehid dehidrogenaza (nespicifična), ABAL dehidrogenaza, 4-aminobutiraldehidna dehidrogenaza, 4-aminobutanalna dehidrogenaza, gama-aminobutiraldehidna dehidroganase, 1-pirolidinska dehidrogenaza, ABALDH, YdcW) je enzim sa sistematskim imenom 4-aminobutanal:NAD+ 1-oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-aminobutanal + NAD+ +H2O 4-aminobutanoat + NADH + 2 H+
Ovaj enzim manifestuje široku supstratnu specifičnost i ima znatnu preferenciju za pravolančane aldehide kao supstrate (do 7 ugljenika duge). Biljni enzim takođe deluje na 4-guanidinobutanal (cf. EC 1.2.1.54 gama-guanidinobutiraldehid dehidrogenazu). 1-pirolidin i 4-aminobutanal su u ravnoteži i mogu se spontano interkonvertovati. 1-pirolidin može da deluje kao početni supstrat. Ovaj enzim formira deo argininskog kataboličkog puta i pripada superfamiliji aldehidnih dehidrogenaza.
Reference[уреди | уреди извор]
- ^ Callewaert, D.M., Rosemblatt, M.S. and Tchen, T.T. (1974). „Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species”. J. Biol. Chem. 249: 1737—1741. PMID 4817964.
- ^ Jakoby, W.B. (1963). „Aldehyde dehydrogenases”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 7 (2nd изд.). New York: Academic Press. стр. 203—221.
- ^ Jakoby, W.B. & Fredericks, J. (1959). „Pyrrolidine and putrescine metabolism: γ-aminobutyraldehyde dehydrogenase”. J. Biol. Chem. 234: 2145—2150. PMID 13673029.
- ^ Matsuda, H. & Suzuki, Y. (1984). „γ-Guanidinobutyraldehyde dehydrogenase of Vicia faba leaves”. Plant Physiol. 76: 654—657. PMID 16663901.
- ^ Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K. (1986). „4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida”. Agric. Biol. Chem. 50: 2009—2016.
- ^ Prieto-Santos, M.I., Martin-Checa, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1986). „A pathway for putrescine catabolism in Escherichia coli”. Biochim. Biophys. Acta. 880: 242—244. PMID 3510672.
- ^ Prieto, M.I., Martin, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1987). „Properties of γ-aminobutyraldehyde dehydrogenase from Escherichia coli”. Biochimie. 69: 1161—1168. PMID 3129020.
- ^ Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R. (2005). „Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase”. FEBS Lett. 579: 4107—4112. PMID 16023116.
- ^ Gruez, A., Roig-Zamboni, V., Grisel, S., Salomoni, A., Valencia, C., Campanacci, V., Tegoni, M. and Cambillau, C. (2004). „Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase”. J. Mol. Biol. 343: 29—41. PMID 15381418.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Aminobutyraldehyde+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
