Aminopeptidaza S
| Aminopeptidaza S | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.24 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminopeptidaza S (EC 3.4.11.24, Mername-AA022 peptidaza, SGAP, aminopeptidaza (Streptomyces griseus), Streptomyces griseus aminopeptidaza, S. griseus AP, dvostruka-cinkova aminopeptidaza) je enzim sa sistematskim imenom '.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne aminokiseline sa preferencijom za velike hidrofobne amino-terminuske ostatke
Aminopeptidaze imaju mnoštovo bioloških funkcija, uključujući maturaciju proteina, proteinsku degradaciju, kontrolu ćelijskog ciklusa i regulaciju hormonskih nivoa.
Reference[уреди | уреди извор]
- ^ Spungin, A. & Blumberg, S. (1989). „Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme”. Eur. J. Biochem. 183: 471—477. PMID 2503378.
- ^ Ben-Meir, D., Spungin, A., Ashkenazi, R. and Blumberg, S. (1993). „Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution”. Eur. J. Biochem. 212: 107—112. PMID 8444149.
- ^ Arima, J., Uesugi, Y., Iwabuchi, M. and Hatanaka, T. (2006). „Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica”. Appl. Microbiol. Biotechnol. 70: 541—547. PMID 16080009.
- ^ Fundoiano-Hershcovitz, Y., Rabinovitch, L., Langut, Y., Reiland, V., Shoham, G. and Shoham, Y. (2004). „Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus”. FEBS Lett. 571: 192—196. PMID 15280041.
- ^ Gilboa, R., Greenblatt, H.M., Perach, M., Spungin-Bialik, A., Lessel, U., Wohlfahrt, G., Schomburg, D., Blumberg, S. and Shoham, G. (2000). „Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 Å resolution”. Acta Crystallogr. D Biol. Crystallogr. 56: 551—558. PMID 10771423.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Aminopeptidase+S на US National Library of Medicine Medical Subject Headings (MeSH)
