Atrolizin C

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Atrolizin C
Identifikatori
EC broj 3.4.24.42
CAS broj 158886-17-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Atrolizin C (EC 3.4.24.42, Crotalus atrox metaloendopeptidaza c, hemoragijsk toksin c, hemoragijski toksin d) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu i Gly23-Phe veza u B lancu insulina. Na malim molekulima postoji preferencija za hidrofobne ostatke u P2' i male ostatke poput Ala, Gly u P1

Ova hemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.

Reference[уреди]

  1. ^ Bjarnason, J.B. and Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e“. Biochemistry 17: 3395-3404. PMID 210790. 
  2. ^ Fox, J.W., Campbell, R., Beggerly, L. and Bjarnason, J.B. (1986). „Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom“. Eur. J. Biochem. 156: 65-72. PMID 3514216. 
  3. ^ Bjarnason, J.B. and Fox, J.W. (1987). „Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom“. Biochim. Biophys. Acta 911: 356-363. PMID 3101740. 
  4. ^ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). „Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom“. Arch. Biochem. Biophys. 253: 108-121. PMID 2949699. 
  5. ^ Shannon, J.D., Baramova, E.N., Bjarnason, J.B. and Fox, F.W. (1989). „Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin“. J. Biol. Chem. 264: 11575-11583. PMID 2745407. 
  6. ^ Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- (1990). „2, isolated from the venom of Crotalus ruber ruber“. J. Biochem. (Tokyo) 108: 711-719. PMID 2081731. 

Literatura[уреди]

Spoljašnje vezе[уреди]