BIRC3

Из Википедије, слободне енциклопедије
Bakuloviralni protein 3 koji sadrži IAP ponavljanje

PDB prikaz baziran na 2uvl.
Dostupne strukture
2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Identifikatori
Simboli BIRC3; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2
Vanjski ID OMIM601721 MGI1197007 HomoloGene899 GeneCards: BIRC3 Gene
Pregled RNK izražavanja
PBB GE BIRC3 210538 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 330 11796
Ensembl ENSG00000023445 ENSMUSG00000032000
UniProt Q13489 O08863
RefSeq (mRNA) NM_001165.4 NM_007464.3
RefSeq (protein) NP_001156.1 NP_031490.2
Lokacija (UCSC) Chr 11:
102.19 - 102.21 Mb
Chr 9:
7.85 - 7.87 Mb
PubMed pretraga [1] [2]

Bakulovirusni protein 3 koji sadrži IAP ponavljanje (cIAP2) je protein koji je kod ljudi kodiran BIRC3 genom.[1][2]

cIAP2 je član familije Inhibitora apoptoze koja inhibira apoptozu putem ometanja aktivacije kaspaze. Ovaj pretein inhibra apoptozu indukovanu serumskom deprivacijom, ali nema uticaja na apoptozu koja proizilazi iz izlaganja menadionu, potentnom induktoru slobodnih radikala. cIAP2 protein sadrži tri BIR domensa UBA domen, CARD domen i RING prst domen. Poznato je nekoliko transkriptnih varijanti ovog proteina.[3]

Interakcije[уреди]

Bakulovirusni protein 3 koji sadrži IAP ponavljanje formira interakcije sa TRAF1,[4][5] TRAF2,[4][5][6][7] RIPK1,[8] kaspazom-9[9] i UBE2D2.[10]

Reference[уреди]

  1. ^ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes“. Nature 379 (6563): 349–53. DOI:10.1038/379349a0. PMID 8552191. 
  2. ^ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins“. Cell 83 (7): 1243–52. DOI:10.1016/0092-8674(95)90149-3. PMID 8548810. 
  3. ^ „Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3“. 
  4. ^ а б Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (December 1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases“. EMBO J. (ENGLAND) 16 (23): 6914–25. DOI:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571. 
  5. ^ а б Li, Xiaoming; Yang Yili, Ashwell Jonathan D (March 2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2“. Nature (England) 416 (6878): 345–7. DOI:10.1038/416345a. ISSN 0028-0836. PMID 11907583. 
  6. ^ Uren, A G; Pakusch M, Hawkins C J, Puls K L, Vaux D L (May. 1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors“. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 4974–8. DOI:10.1073/pnas.93.10.4974. ISSN 0027-8424. PMC 39390. PMID 8643514. 
  7. ^ Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein“. J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. DOI:10.1074/jbc.275.15.11114. ISSN 0021-9258. PMID 10753917. 
  8. ^ Bertrand, Mathieu J M; Milutinovic Snezana, Dickson Kathleen M, Ho Wai Chi, Boudreault Alain, Durkin Jon, Gillard John W, Jaquith James B, Morris Stephen J, Barker Philip A (June 2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination“. Mol. Cell (United States) 30 (6): 689–700. DOI:10.1016/j.molcel.2008.05.014. PMID 18570872. 
  9. ^ Deveraux, Q L; Roy N, Stennicke H R, Van Arsdale T, Zhou Q, Srinivasula S M, Alnemri E S, Salvesen G S, Reed J C (April 1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases“. EMBO J. (ENGLAND) 17 (8): 2215–23. DOI:10.1093/emboj/17.8.2215. ISSN 0261-4189. PMC 1170566. PMID 9545235. 
  10. ^ Mace, Peter D; Linke Katrin, Feltham Rebecca, Schumacher Frances-Rose, Smith Clyde A, Vaux David L, Silke John, Day Catherine L (November 2008). „Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment“. J. Biol. Chem. (United States) 283 (46): 31633–40. DOI:10.1074/jbc.M804753200. ISSN 0021-9258. PMID 18784070. 

Literatura[уреди]