CD117

Из Википедије, слободне енциклопедије
V-kit Hardi-Zakerman 4, homolog mačijeg sarkoma viralnog onkogena

PDB prikaz baziran na 1pkg.
Dostupne strukture
1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F
Identifikatori
Simboli KIT; C-Kit; CD117; PBT; SCFR
Vanjski ID OMIM164920 MGI96677 HomoloGene187 GeneCards: KIT Gene
EC broj 2.7.10.1
Ortolozi
Vrsta Čovek Miš
Entrez 3815 16590
Ensembl ENSG00000157404 ENSMUSG00000005672
UniProt P10721 P05532
RefSeq (mRNA) NM_000222.2 NM_001122733.1
RefSeq (protein) NP_000213.1 NP_001116205.1
Lokacija (UCSC) Chr 4:
55.52 - 55.61 Mb
Chr 5:
75.97 - 76.05 Mb
PubMed pretraga [1] [2]

Receptor faktora rasta mastocita/matičnih ćelija (engl. Mast/stem cell growth factor receptor - SCFR), takođe poznat kao proto-onkogen c-Kit ili tirozinska proteinska kinaza Kit ili CD117, je protein koji je kod ljudi kodiran KIT genom.[1] Višestruke transkriptne varijante koje kodiraju različite izoforme ovog gena su poznate.[2] KIT prvi opisao nemački biohemičar Aksel Ulrič 1987. kao ćelijski homolog mačijeg sarkomnog viralnog onkogena v-kit.[3]

Interakcije[уреди]

CD117 formira interakcije sa:

Reference[уреди]

  1. ^ Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX, Galibert F (January 1997). „Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes“. Genomics 39 (2): 216–26. DOI:10.1006/geno.1996.4482. PMID 9027509. 
  2. ^ „Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog“. 
  3. ^ Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (November 1987). „Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand“. EMBO J. 6 (11): 3341–51. PMC 553789. PMID 2448137. 
  4. ^ Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L (March 2003). „The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit“. Biochem. J. 370 (Pt 3): 1033–8. DOI:10.1042/BJ20020716. PMC 1223215. PMID 12444928. 
  5. ^ Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, Druker B, Griffin JD, Emmerich B, Ullrich A (July 1996). „Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells“. Br. J. Haematol. 94 (1): 5–16. DOI:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502. 
  6. ^ а б в Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (June 2002). „C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors“. Blood 99 (12): 4413–21. DOI:10.1182/blood.V99.12.4413. PMID 12036870. 
  7. ^ а б Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (August 2003). „Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk“. Exp. Cell Res. 288 (1): 110–8. DOI:10.1016/S0014-4827(03)00206-4. PMID 12878163. 
  8. ^ а б van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells“. Blood 96 (10): 3406–13. PMID 11071635. 
  9. ^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). „Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)“. J. Biol. Chem. 272 (15): 10248–53. DOI:10.1074/jbc.272.15.10248. PMID 9092574. 
  10. ^ а б Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD (April 2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling“. J. Biol. Chem. 277 (16): 13732–8. DOI:10.1074/jbc.M200277200. PMID 11825908. 
  11. ^ а б Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P (February 2010). „FES kinase participates in KIT-ligand induced chemotaxis“. Biochem. Biophys. Res. Commun. 393 (1): 174–8. DOI:10.1016/j.bbrc.2010.01.116. PMID 20117079. 
  12. ^ Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). „Role for the adaptor protein Grb10 in the activation of Akt“. Mol. Cell. Biol. 22 (4): 979–91. DOI:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791. 
  13. ^ а б в De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). „Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation“. EMBO J. 18 (4): 904–15. DOI:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833. 
  14. ^ Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L (July 1999). „Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor“. Biochem. J. 341 ( Pt 1): 211–6. DOI:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264. 
  15. ^ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). „Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway“. J. Biol. Chem. 271 (21): 12129–32. DOI:10.1074/jbc.271.21.12129. PMID 8647802. 
  16. ^ Lev S, Yarden Y, Givol D (May 1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses“. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232. 
  17. ^ Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (February 1993). „Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor“. J. Biol. Chem. 268 (6): 4399–406. PMID 7680037. 
  18. ^ Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). „Adaptor protein Lnk associates with Tyr(568) in c-Kit“. Biochem. J. 415 (2): 241–5. DOI:10.1042/BJ20080102. PMID 18588518. 
  19. ^ Linnekin D, DeBerry CS, Mou S (October 1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells“. J. Biol. Chem. 272 (43): 27450–5. DOI:10.1074/jbc.272.43.27450. PMID 9341198. 
  20. ^ Jhun BH, Rivnay B, Price D, Avraham H (April 1995). „The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit“. J. Biol. Chem. 270 (16): 9661–6. DOI:10.1074/jbc.270.16.9661. PMID 7536744. 
  21. ^ Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (February 1997). „Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes“. J. Biol. Chem. 272 (9): 5915–20. DOI:10.1074/jbc.272.9.5915. PMID 9038210. 
  22. ^ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity“. FEBS Lett. 482 (1-2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522. 
  23. ^ Serve H, Hsu YC, Besmer P (February 1994). „Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells“. J. Biol. Chem. 269 (8): 6026–30. PMID 7509796. 
  24. ^ Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE (October 1994). „The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells“. J. Biol. Chem. 269 (40): 25206–11. PMID 7523381. 
  25. ^ а б Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA (April 1998). „SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain“. Mol. Cell. Biol. 18 (4): 2089–99. PMC 121439. PMID 9528781. 
  26. ^ Yi T, Ihle JN (June 1993). „Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand“. Mol. Cell. Biol. 13 (6): 3350–8. PMC 359793. PMID 7684496. 
  27. ^ Deberry C, Mou S, Linnekin D (October 1997). „Stat1 associates with c-kit and is activated in response to stem cell factor“. Biochem. J. 327 ( Pt 1): 73–80. PMC 1218765. PMID 9355737. 
  28. ^ Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (March 2004). „Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling“. J. Biol. Chem. 279 (13): 12249–59. DOI:10.1074/jbc.M313381200. PMID 14707129. 
  29. ^ Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L (September 1999). „Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction“. Oncogene 18 (40): 5546–53. DOI:10.1038/sj.onc.1202929. PMID 10523831. 
  30. ^ Tang B, Mano H, Yi T, Ihle JN (December 1994). „Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding“. Mol. Cell. Biol. 14 (12): 8432–7. PMC 359382. PMID 7526158. 

Literatura[уреди]

Vidi još[уреди]

Spoljašnje veze[уреди]