COPG

Koatomerni proteinski kompleks, podjedinica gama
Koatomerni proteinski kompleks, podjedinica gama
	PDB prikaz baziran na 1pzd.
Dostupne strukture
	1pzd, 1r4x
Identifikatori
Simboli	COPG; COPG1; FLJ21068
Vanjski ID	MGI: 1858696 HomoloGene: 56745 GeneCards: COPG Gene
Ontologija gena
Molekularna funkcija	• aktivnost strukturnog molekula; • proteinsko vezivanje;
Celularna komponenta	• Goldžijeva membrana; • citoplazmam; • Goldžijev aparat; • Goldžem potpomognuta vezikula; • citosol; • membrana; • membranski pokrivač; • COPI vezikularni pokrivač; • citoplazmatična vezikula;
Biološki proces	• intracelularni proteinski transport; • retrogradni vezikulom posredovani transport, Goldži do ER; • celularna membranska organizacija; • vezikulom posredovani transport; • COPI pokrivač Goldžijevog aparata;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	22820
Ensembl	ENSG00000181789
UniProt	Q9Y678
RefSeq (mRNA)	NM_016128
RefSeq (protein)	NP_057212
Lokacija (UCSC)	Chr 3:; 128.97 - 129 Mb
PubMed pretraga	[1]

Koatomerna podjedinica gama je protein koji je kod ljudi kodiran COPG genom.^[1]^[2]

Interakcije[уреди | уреди извор]

Za COPG je pokazano da formira interakcije sa dopaminskim receptorom D1,^[3] COPZ1^[4]^[5] i COPB1.^[1]^[6]

Reference[уреди | уреди извор]

^ ^а ^б Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2001). „Identification and characterization of novel isoforms of COP I subunits”. J Biochem. 128 (5): 793—801. PMID 11056392.
^ „Entrez Gene: COPG coatomer protein complex, subunit gamma”.
^ Bermak, Jason C; Li Ming (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. Germany. 81 (2): 77—85. ISSN 0171-9335. PMID 11893085. doi:10.1078/0171-9335-00222.
^
^ Faulstich, D; Auerbach S (1996). „Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex”. J. Cell Biol. UNITED STATES. 135 (1): 53—61. ISSN 0021-9525. PMC 2121028 . PMID 8858162. doi:10.1083/jcb.135.1.53.
^ Lowe, M; Kreis T E (1996). „In vivo assembly of coatomer, the COP-I coat precursor”. J. Biol. Chem. UNITED STATES. 271 (48): 30725—30. ISSN 0021-9258. PMID 8940050. doi:10.1074/jbc.271.48.30725.

Literatura[уреди | уреди извор]

Lowe M, Kreis TE (1997). „In vivo assembly of coatomer, the COP-I coat precursor.”. J. Biol. Chem. 271 (48): 30725—30. PMID 8940050. doi:10.1074/jbc.271.48.30725.
Pavel J, Harter C, Wieland FT (1998). „Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.”. Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140—5. PMC 19276 . PMID 9482852. doi:10.1073/pnas.95.5.2140.
Fischer KD, Helms JB, Zhao L, Wieland FT (2000). „Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.”. Methods. 20 (4): 455—64. PMID 10720466. doi:10.1006/meth.2000.0958.
Eugster A, Frigerio G, Dale M, Duden R (2000). „COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.”. EMBO J. 19 (15): 3905—17. PMC 306616 . PMID 10921873. doi:10.1093/emboj/19.15.3905.
Hu RM; Han ZG; Song HD (2000). „Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”. Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543—8. PMC 16901 . PMID 10931946. doi:10.1073/pnas.160270997.
Sullivan BM; Harrison-Lavoie KJ; Marshansky V (2000). „RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.”. Mol. Biol. Cell. 11 (9): 3155—68. PMC 14982 . PMID 10982407.
Hahn Y; Lee YJ; Yun JH (2000). „Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution.”. FEBS Lett. 482 (1–2): 31—6. PMID 11018518. doi:10.1016/S0014-5793(00)02033-0.
Paulsson KM; Kleijmeer MJ; Griffith J (2002). „Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum”. J. Biol. Chem. 277 (21): 18266—71. PMID 11884415. doi:10.1074/jbc.M201388200.
Bermak JC; Li M; Bullock C (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. 81 (2): 77—85. PMID 11893085. doi:10.1078/0171-9335-00222.
Kanzaki M; Watson RT; Hou JC (2003). „Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes”. Mol. Biol. Cell. 13 (7): 2334—46. PMC 117317 . PMID 12134073. doi:10.1091/mbc.01-10-0490.
Xu Y, Martin S, James DE, Hong W (2003). „GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus”. Mol. Biol. Cell. 13 (10): 3493—507. PMC 129961 . PMID 12388752. doi:10.1091/mbc.E02-01-0004.
Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Rohde HM; Cheong FY; Konrad G (2004). „The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex”. J. Biol. Chem. 278 (52): 52689—99. PMID 14527956. doi:10.1074/jbc.M307983200.
Watson PJ; Frigerio G; Collins BM (2004). „Gamma-COP appendage domain - structure and function”. Traffic. 5 (2): 79—88. PMID 14690497. doi:10.1111/j.1600-0854.2004.00158.x.
Ota T; Suzuki Y; Nishikawa T (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS; Wagner L; Feingold EA (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ewing RM; Chu P; Elisma F (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

[pmid11056392-1] а ^б Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2001). „Identification and characterization of novel isoforms of COP I subunits”. J Biochem. 128 (5): 793—801. PMID 11056392.

[entrez-2] „Entrez Gene: COPG coatomer protein complex, subunit gamma”.

[pmid11893085-3] Bermak, Jason C; Li Ming (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. Germany. 81 (2): 77—85. ISSN 0171-9335. PMID 11893085. doi:10.1078/0171-9335-00222.

[autogenerated1-4] ^

[pmid8858162-5] Faulstich, D; Auerbach S (1996). „Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex”. J. Cell Biol. UNITED STATES. 135 (1): 53—61. ISSN 0021-9525. PMC 2121028 . PMID 8858162. doi:10.1083/jcb.135.1.53.

[pmid8940050-6] Lowe, M; Kreis T E (1996). „In vivo assembly of coatomer, the COP-I coat precursor”. J. Biol. Chem. UNITED STATES. 271 (48): 30725—30. ISSN 0021-9258. PMID 8940050. doi:10.1074/jbc.271.48.30725.

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