D-treoninska aldolaza

С Википедије, слободне енциклопедије
D-treoninska aldolaza
Identifikatori
EC broj4.1.2.42
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

D-treoninska aldolaza (EC 4.1.2.42, D-TA, DTA, nisko specifična D-TA, nisko specifična D-treoninska aldolaza) je enzim sa sistematskim imenom D-treonin acetaldehid-lijaza (formira glicin).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) D-treonin glicin + acetaldehid
(2) D-alotreonin glicin + acetaldehid

Ovaj piridoksal-fosfatni protein aktiviraju divalentni metalni katjoni (e.g. Co2+, Ni2+, Mn2+ or Mg2+).

Reference[уреди | уреди извор]

  1. ^ Kataoka, M., Ikemi, M., Morikawa, T., Miyoshi, T., Nishi, K., Wada, M., Yamada, H. and Shimizu, S. (1997). „Isolation and characterization of D-threonine aldolase, a pyridoxal-5′-phosphate-dependent enzyme from Arthrobacter sp. DK-38”. Eur. J. Biochem. 248: 385—393. PMID 9346293. 
  2. ^ Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. (1998). „A novel metal-activated pyridoxal enzyme with a unique primary structure, low specificity D-threonine aldolase from Arthrobacter sp. Strain DK-38. Molecular cloning and cofactor characterization”. J. Biol. Chem. 273: 16678—16685. PMID 9642221. 
  3. ^ Liu, J.Q., Odani, M., Dairi, T., Itoh, N., Shimizu, S. and Yamada, H. (1999). „A new route to L-threo-3-[4-(methylthio)phenylserine], a key intermediate for the synthesis of antibiotics: recombinant low-specificity D-threonine aldolase-catalyzed stereospecific resolution”. Appl. Microbiol. Biotechnol. 51: 586—591. PMID 10390816. 
  4. ^ Liu, J.Q., Odani, M., Yasuoka, T., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. (2000). „Gene cloning and overproduction of low-specificity D-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug”. Appl. Microbiol. Biotechnol. 54: 44—51. PMID 10952004. 
  5. ^ Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. (2000). „Diversity of microbial threonine aldolases and their application”. J. Mol. Catal. B. 10: 107—115. 
  6. ^ Paiardini, A., Contestabile, R., D'Aguanno, S., Pascarella, S. and Bossa, F. (2003). „Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes”. Biochim. Biophys. Acta. 1647: 214—219. PMID 12686135. 

Literatura[уреди | уреди извор]

Spoljašnje veze[уреди | уреди извор]