LIG1
(преусмерено са DNK ligaza I)
| Ligaza I, DNK, ATP zavisna | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| Dostupne strukture | |||||||||||
| 1X9N | |||||||||||
| Identifikatori | |||||||||||
| Simboli | LIG1; MGC117397; MGC130025 | ||||||||||
| Vanjski ID | OMIM: 126391 MGI: 101789 HomoloGene: 197 GeneCards: LIG1 Gene | ||||||||||
| EC broj | 6.5.1.1 | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3978 | 16881 | |||||||||
| Ensembl | ENSG00000105486 | ENSMUSG00000056394 | |||||||||
| UniProt | P18858 | P37913 | |||||||||
| RefSeq (mRNA) | NM_000234.1 | NM_001083188.1 | |||||||||
| RefSeq (protein) | NP_000225.1 | NP_001076657.1 | |||||||||
| Lokacija (UCSC) |
Chr 19: 48.62 - 48.67 Mb |
Chr 7: 13.86 - 13.9 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
DNK ligaza 1 je enzim koji je kod ljudi kodiran LIG1 genom. On učestvuje u replikaciji DNK i procesu popravke. Mutacije LIG1 koje proizvode deficijenciju DNK ligaze I rezultuju u imunodeficijenciji i povećanoj senzitivnosti na agense koji oštećuju DNK.[1]
Reference[уреди | уреди извор]
Literatura[уреди | уреди извор]
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- Barnes DE; Kodama K; Tynan K; et al. (1992). „Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3.”. Genomics. 12 (1): 164—6. PMID 1733856. doi:10.1016/0888-7543(92)90422-O.
- Petrini JH, Huwiler KG, Weaver DT (1991). „A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7615—9. PMC 52352
. PMID 1881902. doi:10.1073/pnas.88.17.7615. - Lasko DD, Tomkinson AE, Lindahl T (1990). „Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I.”. J. Biol. Chem. 265 (21): 12618—22. PMID 2197279.
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- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1-2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Rossi R; Villa A; Negri C; et al. (1999). „The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I.”. EMBO J. 18 (20): 5745—54. PMC 1171641 . PMID 10523317. doi:10.1093/emboj/18.20.5745.
- Matsumoto Y; Kim K; Hurwitz J; et al. (1999). „Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.”. J. Biol. Chem. 274 (47): 33703—8. PMID 10559261. doi:10.1074/jbc.274.47.33703.
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