Diadenozin heksafosfatna hidrolaza (formira AMP)
| Diadenozin heksafosfatna hidrolaza (formira AMP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.60 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diadenozin heksafosfatna hidrolaza (formira AMP) (EC 3.6.1.60, hAps1, NUDT11 (gen), hAps2, NUDT10 (gen)) je enzim sa sistematskim imenom P1,P6-bis(5'-adenozil)heksafosfat nukleotidohidrolaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) P1,P6-bis(5'-adenozil)heksafosfat + H2O adenozin 5'-pentafosfat + AMP
- (2) P1,P5-bis(5'-adenozil)pentafosfat + H2O adenozin 5'-tetrafosfat + AMP
Dvovalentni kation je esencijalan za aktivnost.
Reference[уреди | уреди извор]
- ^ Leslie, N.R., McLennan, A.G. and Safrany, S.T. (2002). „Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases”. BMC Biochem. 3: #20—20. PMID 12121577.
- ^ Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D. and Shears, S.B. (1999). „The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein”. J. Biol. Chem. 274: 21735—21740. PMID 10419486.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Diadenosine+hexaphosphate+hydrolase+(AMP-forming) на US National Library of Medicine Medical Subject Headings (MeSH)
