Folitropinska podjedinica beta

Из Википедије, слободне енциклопедије
(преусмерено са FSHB)
Folikostimulišući hormon, beta polipeptid

PDB prikaz baziran na 1fl7.
Dostupne strukture
1FL7, 1XWD, 4AY9
Identifikatori
Simbol FSHB
Vanjski ID OMIM136530 MGI95582 HomoloGene430 GeneCards: FSHB Gene
Pregled RNK izražavanja
PBB GE FSHB 214489 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2488 14308
Ensembl ENSG00000131808 ENSMUSG00000027120
UniProt P01225 Q60687
RefSeq (mRNA) NM_000510.2 NM_008045.2
RefSeq (protein) NP_000501.1 NP_032071.1
Lokacija (UCSC) Chr 11:
30.25 - 30.26 Mb
Chr 2:
107.06 - 107.06 Mb
PubMed pretraga [1] [2]

Folitropinska podjedinica beta (beta podjedica folikostimulišućeg hormona, FSH-B) je protein koji je kod ljudi kodiran FSHB genom.[1][2][3] Alternativno splajsovanje proizvodi dve transkriptne varijante koji kodiraju isti protein.

Funkcija[уреди]

Hipofizna glikoproteinska hormonska familija obuhvata folikulostimulišući hormon, luteinizirajući hormon, humani horionski gonadotropin, i tireostimulišući hormon. Svi ti glikoproteini sadrže identičnu alfa podjedinicu i hormon specifičnu beta podjedinicu. Ovaj gen kodira beta podjedinicu folikul-stimulišućeg hormona. Zajedno sa luteinizirajućim hormonom, folikulostimulišuć hormon indukuje produkciju jaja i sperme.[3]

Reference[уреди]

  1. ^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). „DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11“. DNA 6 (3): 205–12. DOI:10.1089/dna.1987.6.205. PMID 2885163. 
  2. ^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). „A reevaluation of the amino acid sequence of human follitropin beta-subunit“. J Protein Chem 7 (4): 325–39. DOI:10.1007/BF01024882. PMID 3151250. 
  3. ^ а б „Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide“. 

Literatura[уреди]

  • Barrios-De-Tomasi J, Timossi C, Merchant H et al. (2002). „Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones“. Mol. Cell. Endocrinol. 186 (2): 189–98. DOI:10.1016/S0303-7207(01)00657-8. PMID 11900895. 
  • Saxena BB, Rathnam P (1976). „Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands“. J. Biol. Chem. 251 (4): 993–1005. PMID 1249074. 
  • Keene JL, Matzuk MM, Otani T et al. (1989). „Expression of biologically active human follitropin in Chinese hamster ovary cells“. J. Biol. Chem. 264 (9): 4769–75. PMID 2494176. 
  • Jameson JL, Becker CB, Lindell CM, Habener JF (1988). „Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids“. Mol. Endocrinol. 2 (9): 806–15. DOI:10.1210/mend-2-9-806. PMID 3139991. 
  • Shome B, Parlow AF (1974). „Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)“. J. Clin. Endocrinol. Metab. 39 (1): 203–5. DOI:10.1210/jcem-39-1-203. PMID 4835136. 
  • Fujiki Y, Rathnam P, Saxena BB (1980). „Studies on the disulfide bonds in human pituitary follicle-stimulating hormone“. Biochim. Biophys. Acta 624 (2): 428–35. PMID 6774759. 
  • Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). „Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men“. Cell Tissue Res. 278 (3): 595–600. DOI:10.1007/BF00331379. PMID 7850869. 
  • Matthews CH, Borgato S, Beck-Peccoz P et al. (1993). „Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone“. Nat. Genet. 5 (1): 83–6. DOI:10.1038/ng0993-83. PMID 8220432. 
  • Layman LC, Lee EJ, Peak DB et al. (1997). „Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene“. N. Engl. J. Med. 337 (9): 607–11. DOI:10.1056/NEJM199708283370905. PMID 9271483. 
  • Cargill M, Altshuler D, Ireland J et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes“. Nat. Genet. 22 (3): 231–8. DOI:10.1038/10290. PMID 10391209. 
  • Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). „Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle“. Regul. Pept. 81 (1–3): 67–71. DOI:10.1016/S0167-0115(99)00022-1. PMID 10395410. 
  • Ben-Menahem D, Hyde R, Pixley M et al. (1999). „Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation“. Biochemistry 38 (46): 15070–7. DOI:10.1021/bi991510c. PMID 10563789. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags“. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. DOI:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Hartley JL, Temple GF, Brasch MA (2001). „DNA Cloning Using In Vitro Site-Specific Recombination“. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Fox KM, Dias JA, Van Roey P (2001). „Three-dimensional structure of human follicle-stimulating hormone“. Mol. Endocrinol. 15 (3): 378–89. DOI:10.1210/me.15.3.378. PMID 11222739. 
  • Amoresano A, Orrù S, Siciliano RA et al. (2002). „Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain“. Biol. Chem. 382 (6): 961–8. DOI:10.1515/BC.2001.120. PMID 11501762. 
  • Walton WJ, Nguyen VT, Butnev VY et al. (2001). „Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit“. J. Clin. Endocrinol. Metab. 86 (8): 3675–85. DOI:10.1210/jc.86.8.3675. PMID 11502795.