Fragilizin

Из Википедије, слободне енциклопедије
Fragilizin
Identifikatori
EC broj 3.4.24.74
CAS broj 188596-63-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Fragilizin (EC 3.4.24.74, Bacteroides fragilis (entero)toksin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Širokoa proteolitička specifičnost, između ostalog dolazi do hidrolize veza -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly

Smatra se da je ovaj enzim uzročnik dijareje kod životinja i ljudi.

Reference[уреди]

  1. ^ Moncrief, J.S., Obiso, R., Jr., Barroso, L.A., Kling, J.J., Wright, R.L., Van Tassell, R.L., Lyerly, D.M. and Wilkins, T.D. (1995). „The enterotoxin of Bacteroides fragilis is a metalloprotease“. Infect. Immun. 63: 175-181. PMID 7806355. 
  2. ^ Obiso, R.J., Jr., Lyerly, D.M., Van Tassell, R.L. and Wilkins, T.D. (1995). „Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo“. Infect. Immun. 63: 3820-3826. PMID 7558286. 
  3. ^ Donelli, G., Fabbri, A. and Fiorentini, C. (1996). „Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells“. Infect. Immun. 64: 113-119. PMID 8557328. 
  4. ^ Koshy, S.S., Montrose, M.H. and Sears, C.L. (1996). „Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis“. Infect. Immun. 64: 5022-5028. PMID 8945541. 
  5. ^ Kling, J.J., Wright, R.L., Moncrief, J.S. and Wilkins, T.D. (1997). „Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis“. FEMS Microbiol. Lett. 146: 279-284. PMID 9011050. 

Literatura[уреди]

Spoljašnje vezе[уреди]