GABA transporter tip 1

Из Википедије, слободне енциклопедије
Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
Simboli SLC6A1; GABATHG; GABATR; GAT1
Vanjski ID OMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
Pregled RNK izražavanja
PBB GE SLC6A1 205152 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042.3 NM_178703.4
RefSeq (protein) NP_003033.3 NP_848818.1
Lokacija (UCSC) Chr 3:
11.03 - 11.08 Mb
Chr 6:
114.28 - 114.32 Mb
PubMed pretraga [1] [2]

GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.[1][2]

Funkcija[уреди]

GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.[3]

Interakcije[уреди]

SLC6A1 formira interakcije sa STX1A.[4][5][6]

Reference[уреди]

  1. Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25“. Genomics 29 (1): 302–4. DOI:10.1006/geno.1995.1253. PMID 8530094. 
  2. „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1“. 
  3. Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity“. Pharmacogenet. Genomics 19 (1): 53–65. DOI:10.1097/FPC.0b013e328318b21a. PMID 19077666. 
  4. Beckman, M L; Bernstein E M, Quick M W (August 1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A“. J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305. 
  5. Quick, Michael W (April 2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner“. Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. DOI:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023. 
  6. Deken, S L; Beckman M L, Boos L, Quick M W (October 2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A“. Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. DOI:10.1038/79939. ISSN 1097-6256. PMID 11017172. 

Literatura[уреди]

Vidi još[уреди]