GABA transporter tip 1

Из Википедије, слободне енциклопедије
Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
Simboli SLC6A1; GABATHG; GABATR; GAT1
Vanjski ID OMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
Pregled RNK izražavanja
PBB GE SLC6A1 205152 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042.3 NM_178703.4
RefSeq (protein) NP_003033.3 NP_848818.1
Lokacija (UCSC) Chr 3:
11.03 - 11.08 Mb
Chr 6:
114.28 - 114.32 Mb
PubMed pretraga [1] [2]

GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.[1][2]

Funkcija[уреди]

GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.[3]

Interakcije[уреди]

SLC6A1 formira interakcije sa STX1A.[4][5][6]

Reference[уреди]

  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25“. Genomics 29 (1): 302–4. DOI:10.1006/geno.1995.1253. PMID 8530094. 
  2. ^ „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1“. 
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity“. Pharmacogenet. Genomics 19 (1): 53–65. DOI:10.1097/FPC.0b013e328318b21a. PMID 19077666. 
  4. ^ Beckman, M L; Bernstein E M, Quick M W (August 1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A“. J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305. 
  5. ^ Quick, Michael W (April 2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner“. Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. DOI:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023. 
  6. ^ Deken, S L; Beckman M L, Boos L, Quick M W (October 2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A“. Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. DOI:10.1038/79939. ISSN 1097-6256. PMID 11017172. 

Literatura[уреди]

Vidi još[уреди]