GNAI2

Из Википедије, слободне енциклопедије
Guanin nukleotid-vezujući protein (G protein), alfa inhibirajući polipeptid 2
Identifikatori
Simboli GNAI2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Vanjski ID OMIM139360 MGI95772 HomoloGene55539 GeneCards: GNAI2 Gene
Pregled RNK izražavanja
PBB GE GNAI2 201040 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2771 14678
Ensembl ENSG00000114353 n/a
UniProt P04899 n/a
RefSeq (mRNA) NM_002070 XM_980919
RefSeq (protein) NP_002061 XP_986013
Lokacija (UCSC) Chr 3:
50.24 - 50.27 Mb
n/a
PubMed pretraga [1] [2]

GNAI2, Guanin nukleotid-vezujući protein G(i), alfa-2 podjedinica, je protein koji je kod ljudi kodiran GNAI2 genom.[1][2][3]


Interakcije[уреди]

Za GNAI2 je bilo pokazano da formira interakcije sa GPSM2,[4][5] RIC8A,[6] Interleukin 8 receptor, alpha,[7][8] EYA2,[9] RGS5[10][11] i MDFI.[12]

Literatura[уреди]

  1. ^ Didsbury JR, Ho YS, Snyderman R (Mar 1987). „Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA“. FEBS Lett 211 (2): 160–4. DOI:10.1016/0014-5793(87)81428-X. PMID 3100330. 
  2. ^ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (Mar 1992). „Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13“. Genomics 12 (1): 125–9. DOI:10.1016/0888-7543(92)90414-N. PMID 1733849. 
  3. ^ „Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2“. 
  4. ^ Marty, Caroline; Browning Darren D, Ye Richard D (Jun. 2003). „Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras“. Mol. Cell. Biol. (United States) 23 (11): 3847–58. DOI:10.1128/MCB.23.11.3847-3858.2003. ISSN 0270-7306. PMC 155206. PMID 12748287. 
  5. ^ Mochizuki, N; Cho G, Wen B, Insel P A (Nov. 1996). „Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2“. Gene (NETHERLANDS) 181 (1-2): 39–43. DOI:10.1016/S0378-1119(96)00456-8. ISSN 0378-1119. PMID 8973305. 
  6. ^ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (Mar. 2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor“. J. Biol. Chem. (United States) 278 (10): 8356–62. DOI:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  7. ^ Damaj, B B; McColl S R, Neote K, Songqing N, Ogborn K T, Hébert C A, Naccache P H (Oct. 1996). „Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops“. FASEB J. (UNITED STATES) 10 (12): 1426–34. ISSN 0892-6638. PMID 8903513. 
  8. ^ Damaj, B B; McColl S R, Mahana W, Crouch M F, Naccache P H (May. 1996). „Physical association of Gi2alpha with interleukin-8 receptors“. J. Biol. Chem. (UNITED STATES) 271 (22): 12783–9. DOI:10.1074/jbc.271.22.12783. ISSN 0021-9258. PMID 8662698. 
  9. ^ Fan, X; Brass L F, Poncz M, Spitz F, Maire P, Manning D R (Oct. 2000). „The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins“. J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. DOI:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. 
  10. ^ Chen, C; Zheng B, Han J, Lin S C (Mar. 1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast“. J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  11. ^ Zhou, J; Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb. 2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling“. Life Sci. (England) 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 
  12. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). „Towards a proteome-scale map of the human protein-protein interaction network“. Nature (England) 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 

Dodatna literatura[уреди]