GNAO1

Из Википедије, слободне енциклопедије
Guanin nukleotid-vezujući protein (G protein), podjedinica koja aktivira polipeptid O
Identifikatori
Simboli GNAO1; DKFZp686O0962; G-ALPHA-o; GNAO
Vanjski ID OMIM139311 MGI95775 HomoloGene39203 GeneCards: GNAO1 Gene
Pregled RNK izražavanja
PBB GE GNAO1 204762 s at tn.png
PBB GE GNAO1 204763 s at tn.png
PBB GE GNAO1 215912 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2775 14681
Ensembl ENSG00000087258 ENSMUSG00000031748
UniProt P09471 Q543S2
RefSeq (mRNA) NM_020988 NM_010308
RefSeq (protein) NP_066268 NP_034438
Lokacija (UCSC) Chr 16:
54.78 - 54.95 Mb
Chr 8:
96.7 - 96.86 Mb
PubMed pretraga [1] [2]

GNAO1, Guanin nukleotid-vezujući protein G(o), podjedinica alfa, je protein koji je kod čoveka kodiran GNAO1 genom.[1][2][3]

Interakcije[уреди]

Za GNAO1 je bilo pokazano da interaguje sa RGS20,[4] RGS19,[5][6] RIC8A[7] i RGS5.[8][9]

Literatura[уреди]

  1. ^ Murtagh JJ Jr, Eddy R, Shows TB, Moss J, Vaughan M (Mar 1991). „Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16“. Mol Cell Biol 11 (2): 1146–55. PMC 359797. PMID 1899283. 
  2. ^ Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (Jul 2001). „Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels“. J Biol Chem 276 (31): 28731–8. DOI:10.1074/jbc.M104806200. PMID 11395521. 
  3. ^ „Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O“. 
  4. ^ Pagano, Mario; Jordan J Dedrick, Neves Susana R, Nguyen Tracy, Iyengar Ravi (Jun. 2008). „Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways“. Cell. Signal. (England) 20 (6): 1190–7. DOI:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMID 18407463. 
  5. ^ De Vries, L; Elenko E, Hubler L, Jones T L, Farquhar M G (Dec. 1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits“. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. DOI:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 
  6. ^ Woulfe, D S; Stadel J M (Jun. 1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP“. J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. DOI:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. 
  7. ^ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (Mar. 2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor“. J. Biol. Chem. (United States) 278 (10): 8356–62. DOI:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  8. ^ Chen, C; Zheng B, Han J, Lin S C (Mar. 1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast“. J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  9. ^ Zhou, J; Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb. 2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling“. Life Sci. (England) 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 

Dodatna literatura[уреди]