Galaktozildiacilglicerol a-2,3-sijaliltransferaza
| Galaktozildiacilglicerol a-2,3-sijaliltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.5 | ||||||||
| CAS broj | 80237-98-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Galaktozildiacilglicerol a-2,3-sijaliltransferaza (EC 2.4.99.5, Galactosyldiacylglycerol alpha-2,3-sialyltransferase) je enzim sa sistematskim imenom CMP-N-acetil-beta-neuraminat:1,2-diacil-3-beta-D-galaktozil-sn-glicerol N-acetilneuraminiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetil-beta-neuraminat + 1,2-diacil-3-beta-D-galaktozil-sn-glicerol CMP + 1,2-diacil-3-[3-(N-acetil-alfa-D-neuraminil)-beta-D-galaktozil]-sn-glicerol
Beta-D-galaktozilni ostatak oligosaharida glikoproteina takođe može da deluje kao akceptor.
Reference[уреди | уреди извор]
- ^ Pieringer, J., Keech, S. and Pieringer, R.A. (1981). „Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes”. J. Biol. Chem. 256: 12306—12309. PMID 7298658.
- ^ Weinstein, J., de Souza-e-Silva, U. and Paulson, J.C. (1982). „Purification of a Gal β1→4GlcNAc α2→6 sialyltransferase and a Gal β1→3(4)GlcNAc α2→3 sialyltransferase to homogeneity from rat liver”. J. Biol. Chem. 257: 13835—13844. PMID 7142179.
- ^ Weinstein, J., de Souza-e-Silva, U. and Paulson, J.C. (1982). „Sialylation of glycoprotein oligosaccharides N-linked to asparagine. Enzymatic characterization of a Gal β1→3(4)GlcNAc α2→3 sialyltransferase and a Gal β1→4GlcNAc α2→6 sialyltransferase from rat liver”. J. Biol. Chem. 257: 13845—13853. PMID 7142180.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Galactosyldiacylglycerol+alpha-2,3-sialyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
