Glicin N-metiltransferaza
| Glicin N-metiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.1.1.20 | ||||||||
| CAS broj | 37228-72-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glicin N-metiltransferaza (EC 2.1.1.20, glicinska metiltransferaza, S-adenozil-L-metionin:glicin metiltransferaza, GNMT) je enzim sa sistematskim imenom S-adenozil-L-metionin:glicin N-metiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim učestvuje u regulaciji metabolizma metil grupe u jetri i pankreasu putem regulacije odnosa između S-adenozil-L-metionina i S-adenozil-L-homocisteina.
Reference[уреди | уреди извор]
- ^ Blumenstein, J. & Williams, G.R. (1963). „Glycine methyltransferase”. Can. J. Biochem. Physiol. 41: 201—210. PMID 13971907.
- ^ Ogawa, H., Gomi, T., Takusagawa, F. and Fujioka, M. (1998). „Structure, function and physiological role of glycine N-methyltransferase”. Int. J. Biochem. Cell Biol. 30: 13—26. PMID 9597750.
- ^ Yeo, E.J., Briggs, W.T. and Wagner, C. (1999). „Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate”. J. Biol. Chem. 274: 37559—37564. PMID 10608809.
- ^ Martinov, M.V., Vitvitsky, V.M., Mosharov, E.V., Banerjee, R. and Ataullakhanov, F.I. (2000). „A substrate switch: a new mode of regulation in the methionine metabolic pathway”. J. Theor. Biol. 204: 521—532. PMID 10833353.
- ^ Takata, Y., Huang, Y., Komoto, J., Yamada, T., Konishi, K., Ogawa, H., Gomi, T., Fujioka, M. and Takusagawa, F. (2003). „Catalytic mechanism of glycine N-methyltransferase”. Biochemistry. 42: 8394—8402. PMID 12859184.
- ^ Pakhomova, S., Luka, Z., Grohmann, S., Wagner, C. and Newcomer, M.E. (2004). „Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes”. Proteins. 57: 331—337. PMID 15340920.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Glycine+N-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
