Glikogenin glukoziltransferaza

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Glikogenin glukoziltransferaza
Rabbit muscle glycogenin structure.jpg
Identifikatori
EC broj 2.4.1.186
CAS broj 117590-73-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glikogenin glukoziltransferaza (EC 2.4.1.186, glikogenin, prajmirajuća glukoziltransferaza, UDP-glukoza:glikogenin glukoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:glikogenin alfa-D-glukoziltransferaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-glukoza + glikogenin \rightleftharpoons UDP + alfa-D-glukozilglikogenin

Ovaj enzim prvo katalizuje sopstvenu glukozilaciju, normalno na Tyr-194 proteina ako je grupa slobodna. On zatim vrši glukozilaciju glukozilnih grupa dok se formira molekul sa 5--13 ostataka. Dalje produžavanje glikogenskog lanca izvodi enzim EC 2.4.1.11, glikogen (skrob) sintaza.

Reference[уреди]

  1. ^ Krisman, C.R. and Barengo, R. (1975). „A precursor of glycogen biosynthesis: α-1,4-glucan-protein“. Eur. J. Biochem. 52: 117-123. PMID 809265. 
  2. ^ Pitcher, J., Smythe, C., Campbell, D.G. and Cohen, P. (1987). „Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin“. Eur. J. Biochem. 169: 497-502. PMID 3121316. 
  3. ^ Pitcher, J., Smythe, C. and Cohen, P. (1988). „Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle“. Eur. J. Biochem. 176: 391-395. PMID 2970965. 
  4. ^ Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen“. In Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. стр. 65-84. 
  5. ^ Rodriguez, I.R. and Whelan, W.J. (1985). „A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine“. Biochem. Biophys. Res. Commun. 132: 829-836. PMID 4062948. 
  6. ^ Lomako, J., Lomako, W.M. and Whelan, W.J. (1988). „A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis“. FASEB J. 2: 3097-3103. PMID 2973423. 
  7. ^ Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „Catalytic activities of glycogenin additional to autocatalytic self-glucosylation“. J. Biol. Chem. 270: 15315-15319. PMID 7797519. 
  8. ^ Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „A new look at the biogenesis of glycogen“. FASEB J. 9: 1126-1137. PMID 7672505. 
  9. ^ Mu, J. and Roach, P.J. (1998). „Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism“. J. Biol. Chem. 273: 34850-34856. PMID 9857012. 
  10. ^ Gibbons, B.J., Roach, P.J. and Hurley, T.D. (2002). „Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin“. J. Mol. Biol. 319: 463-177. PMID 12051921. 

Литература[уреди]

  • Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen“. In Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. стр. 65-84. 

Spoljašnje veze[уреди]